Continues administration of Nano-PSO significantly increased survival of genetic CJD mice

Orli Binyamin, Guy Keller, Kati Frid, Liraz Larush, Shlomo Magdassi, Ruth Gabizon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We have shown previously that Nano-PSO, a nanodroplet formulation of pomegranate seed oil, delayed progression of neurodegeneration signs when administered for a designated period of time to TgMHu2ME199K mice, modeling for genetic prion disease. In the present work, we treated these mice with a self-emulsion formulation of Nano-PSO or a parallel Soybean oil formulation from their day of birth until a terminal disease stage. We found that long term Nano-PSO administration resulted in increased survival of TgMHu2ME199K lines by several months. Interestingly, initiation of treatment at day 1 had no clinical advantage over initiation at day 70, however cessation of treatment at 9 months of age resulted in the rapid loss of the beneficial clinical effect. Pathological studies revealed that treatment with Nano-PSO resulted in the reduction of GAG accumulation and lipid oxidation, indicating a strong neuroprotective effect. Contrarily, the clinical effect of Nano-PSO did not correlate with reduction in the levels of disease related PrP, the main prion marker. We conclude that long term administration of Nano-PSO is safe and may be effective in the prevention/delay of onset of neurodegenerative conditions such as genetic CJD.

Original languageAmerican English
Pages (from-to)140-147
Number of pages8
JournalNeurobiology of Disease
Volume108
DOIs
StatePublished - Dec 2017

Bibliographical note

Publisher Copyright:
© 2017

Keywords

  • GAGs
  • Genetic
  • Nano-PSO
  • Nanotechnology
  • Pomegranate
  • Prions

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