Continuous chromosomal instability in human pluripotent stem cells–the role of DNA replication

Noa Lamm; Batsheva Kerem

doi:10.1080/23723556.2016.1183743

Continuous chromosomal instability in human pluripotent stem cells–the role of DNA replication

Noa Lamm, Batsheva Kerem^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Human pluripotent stem cells (hPSCs) frequently acquire chromosomal aberrations, including aneuploidy, during culture. Recently, we identified a replication stress-based mechanism leading to ongoing chromosomal instability in aneuploid hPSCs that may also operate during the initiation of instability in diploid cells.

Original language	American English
Article number	e1183743
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2016.1183743
State	Published - 3 Jul 2016

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Publisher Copyright:
© 2016, © 2016 Taylor & Francis Group, LLC.

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10.1080/23723556.2016.1183743

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title = "Continuous chromosomal instability in human pluripotent stem cells–the role of DNA replication",

abstract = "Human pluripotent stem cells (hPSCs) frequently acquire chromosomal aberrations, including aneuploidy, during culture. Recently, we identified a replication stress-based mechanism leading to ongoing chromosomal instability in aneuploid hPSCs that may also operate during the initiation of instability in diploid cells.",

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AU - Kerem, Batsheva

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Continuous chromosomal instability in human pluripotent stem cells–the role of DNA replication

Abstract

Bibliographical note

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