Continuous photochemical cleavage of linkers for solid-phase synthesis

Mattan Hurevich, Jeyakumar Kandasamy, Bopanna M. Ponnappa, Mayeul Collot, Daniel Kopetzki, D. Tyler McQuade, Peter H. Seeberger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Photolabile linkers are an attractive alternative for solid-phase synthesis because they can be cleaved using light. However, irradiation in a classical batch photoreactor results in incomplete cleavage of the photolabile linkers. It is demonstrated that a continuous flow photoreactor is superior to a batch photoreactor for the cleavage of a linker from polystyrene resin.

Original languageAmerican English
Pages (from-to)1794-1797
Number of pages4
JournalOrganic Letters
Volume16
Issue number6
DOIs
StatePublished - 21 Mar 2014
Externally publishedYes

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