TY - JOUR
T1 - Contrasting time course of catecholamine accumulation and of spontaneous discharge in experimental neuromas in the rat
AU - Goldstein, Ronald S.
AU - Raber, Pnina
AU - Govrin-Lippmann, Ruth
AU - Devor, Marshall
PY - 1988/11/22
Y1 - 1988/11/22
N2 - Catecholamine-containing sympathetic axons in rat sciatic nerve-end neuromas were visualized histochemically. Within a few hours of ligating and sectioning the nerve, axons began to accumulate catecholamine histofluorescence. Density of labelled fibers peaked 2-5 days postoperative, then declined rapidly so that little or no label was observed beyond 12 days. Sympathectomy eliminated staining; neonatal treatment with capsaicin had no effect. Accumulation and dissipation of histofluorescence preceded the rise and fall of electrical hyperexcitability in neuromas by several days respectively.
AB - Catecholamine-containing sympathetic axons in rat sciatic nerve-end neuromas were visualized histochemically. Within a few hours of ligating and sectioning the nerve, axons began to accumulate catecholamine histofluorescence. Density of labelled fibers peaked 2-5 days postoperative, then declined rapidly so that little or no label was observed beyond 12 days. Sympathectomy eliminated staining; neonatal treatment with capsaicin had no effect. Accumulation and dissipation of histofluorescence preceded the rise and fall of electrical hyperexcitability in neuromas by several days respectively.
KW - Catecholamine
KW - Causalgia
KW - Nerve injury
KW - Neuroma
KW - Pain
UR - http://www.scopus.com/inward/record.url?scp=0023717414&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(88)90270-4
DO - 10.1016/0304-3940(88)90270-4
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C2 - 2468116
AN - SCOPUS:0023717414
SN - 0304-3940
VL - 94
SP - 58
EP - 63
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -