Contrasting time course of catecholamine accumulation and of spontaneous discharge in experimental neuromas in the rat

Ronald S. Goldstein, Pnina Raber, Ruth Govrin-Lippmann, Marshall Devor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Catecholamine-containing sympathetic axons in rat sciatic nerve-end neuromas were visualized histochemically. Within a few hours of ligating and sectioning the nerve, axons began to accumulate catecholamine histofluorescence. Density of labelled fibers peaked 2-5 days postoperative, then declined rapidly so that little or no label was observed beyond 12 days. Sympathectomy eliminated staining; neonatal treatment with capsaicin had no effect. Accumulation and dissipation of histofluorescence preceded the rise and fall of electrical hyperexcitability in neuromas by several days respectively.

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalNeuroscience Letters
Volume94
Issue number1-2
DOIs
StatePublished - 22 Nov 1988
Externally publishedYes

Keywords

  • Catecholamine
  • Causalgia
  • Nerve injury
  • Neuroma
  • Pain

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