Contribution of activated C3 to lymphocyte-mediated target lysis: Complement-dependent cellular cytotoxicity

Eitan Yefenof; Eva Klein; Ilana Yron

doi:10.1016/0161-5890(84)90012-9

Contribution of activated C3 to lymphocyte-mediated target lysis: Complement-dependent cellular cytotoxicity

Eitan Yefenof^*, Eva Klein, Ilana Yron

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Lysis of Raji cells by human lymphocytes was found to be enhanced if human serum was added to the assay. This was not due to the contribution of antibodies because hypogammaglobulinemic serum also augmented cytotoxicity. The results suggest that the mechanism of the enhancement was due to activation of C3 by the Raji cells. We assume that the cleavage products are deposited on cell surfaces in such a way that they contribute to contact between effector and target. Previous reports in two antibody-dependent cellular cytotoxicity systems provided other examples for the existence of this phenomenon.

Original language	English
Pages (from-to)	1211-1214
Number of pages	4
Journal	Molecular Immunology
Volume	21
Issue number	12
DOIs	https://doi.org/10.1016/0161-5890(84)90012-9
State	Published - Dec 1984

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0161-5890(84)90012-9

Cite this

@article{40896ce76f3142d5b1c21ac41c2b2bef,

title = "Contribution of activated C3 to lymphocyte-mediated target lysis: Complement-dependent cellular cytotoxicity",

abstract = "Lysis of Raji cells by human lymphocytes was found to be enhanced if human serum was added to the assay. This was not due to the contribution of antibodies because hypogammaglobulinemic serum also augmented cytotoxicity. The results suggest that the mechanism of the enhancement was due to activation of C3 by the Raji cells. We assume that the cleavage products are deposited on cell surfaces in such a way that they contribute to contact between effector and target. Previous reports in two antibody-dependent cellular cytotoxicity systems provided other examples for the existence of this phenomenon.",

author = "Eitan Yefenof and Eva Klein and Ilana Yron",

year = "1984",

month = dec,

doi = "10.1016/0161-5890(84)90012-9",

language = "אנגלית",

volume = "21",

pages = "1211--1214",

journal = "Molecular Immunology",

issn = "0161-5890",

publisher = "Elsevier Ltd.",

number = "12",

}

TY - JOUR

T1 - Contribution of activated C3 to lymphocyte-mediated target lysis

T2 - Complement-dependent cellular cytotoxicity

AU - Yefenof, Eitan

AU - Klein, Eva

AU - Yron, Ilana

PY - 1984/12

Y1 - 1984/12

N2 - Lysis of Raji cells by human lymphocytes was found to be enhanced if human serum was added to the assay. This was not due to the contribution of antibodies because hypogammaglobulinemic serum also augmented cytotoxicity. The results suggest that the mechanism of the enhancement was due to activation of C3 by the Raji cells. We assume that the cleavage products are deposited on cell surfaces in such a way that they contribute to contact between effector and target. Previous reports in two antibody-dependent cellular cytotoxicity systems provided other examples for the existence of this phenomenon.

AB - Lysis of Raji cells by human lymphocytes was found to be enhanced if human serum was added to the assay. This was not due to the contribution of antibodies because hypogammaglobulinemic serum also augmented cytotoxicity. The results suggest that the mechanism of the enhancement was due to activation of C3 by the Raji cells. We assume that the cleavage products are deposited on cell surfaces in such a way that they contribute to contact between effector and target. Previous reports in two antibody-dependent cellular cytotoxicity systems provided other examples for the existence of this phenomenon.

UR - http://www.scopus.com/inward/record.url?scp=0021740790&partnerID=8YFLogxK

U2 - 10.1016/0161-5890(84)90012-9

DO - 10.1016/0161-5890(84)90012-9

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 6521746

AN - SCOPUS:0021740790

SN - 0161-5890

VL - 21

SP - 1211

EP - 1214

JO - Molecular Immunology

JF - Molecular Immunology

IS - 12

ER -

Contribution of activated C3 to lymphocyte-mediated target lysis: Complement-dependent cellular cytotoxicity

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this