Contribution of epigenetic mechanisms to variation in cancer risk among tissues

Michael Klutstein, Joshua Moss, Tommy Kaplan, Howard Cedar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Recently, it was suggested that tissue variation in cancer risk originates from differences in the number of stem-cell divisions underlying each tissue, leading to different mutation loads. We show that this variation is also correlated with the degree of aberrant CpG island DNA methylation in normal cells. Methylation accumulates during aging in a subset of molecules, suggesting that the epigenetic landscape within a founder-cell population may contribute to tumor formation.

Original languageAmerican English
Pages (from-to)2230-2234
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number9
StatePublished - 28 Feb 2017

Bibliographical note

Funding Information:
This research was supported by grants from the European Research Council, the Israel Cancer Research Fund, Rosetrees Foundation, Lew Sanders, and the Smart Family Foundation.


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