TY - JOUR
T1 - Control of neurotransmitter release
T2 - From Ca2+ to voltage dependent G-protein coupled receptors
AU - Parnas, Itzchak
AU - Parnas, Hanna
PY - 2010/11
Y1 - 2010/11
N2 - This review discusses two theories that try to explain mechanisms of control of neurotransmitter release in fast synapses: the Ca2+ hypothesis and the Ca2+ voltage hypothesis. The review summarizes experimental results that are incompatible with predictions from the Ca 2+ hypothesis and concludes that Ca2+ is involved in the control of the amount of release but not in the control of the time course of evoked release, i.e., initiation and termination of evoked release. Results summarizing direct effects of changes in membrane potential on the release machinery are then presented. These changes in membrane potential affect the affinity (for the transmitter) of presynaptic autoinhibitory G-protein coupled receptors (GPCRs). The voltage dependence of these GPCRs and their pivotal role in determining the time course of evoked release is discussed.
AB - This review discusses two theories that try to explain mechanisms of control of neurotransmitter release in fast synapses: the Ca2+ hypothesis and the Ca2+ voltage hypothesis. The review summarizes experimental results that are incompatible with predictions from the Ca 2+ hypothesis and concludes that Ca2+ is involved in the control of the amount of release but not in the control of the time course of evoked release, i.e., initiation and termination of evoked release. Results summarizing direct effects of changes in membrane potential on the release machinery are then presented. These changes in membrane potential affect the affinity (for the transmitter) of presynaptic autoinhibitory G-protein coupled receptors (GPCRs). The voltage dependence of these GPCRs and their pivotal role in determining the time course of evoked release is discussed.
KW - GPCRs
KW - M2R
KW - Presynaptic receptor
KW - Synaptic transmission
KW - Transmitter release
UR - http://www.scopus.com/inward/record.url?scp=78549284557&partnerID=8YFLogxK
U2 - 10.1007/s00424-010-0872-7
DO - 10.1007/s00424-010-0872-7
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C2 - 20811904
AN - SCOPUS:78549284557
SN - 0031-6768
VL - 460
SP - 975
EP - 990
JO - Pflugers Archiv European Journal of Physiology
JF - Pflugers Archiv European Journal of Physiology
IS - 6
ER -