Controlled and tunable polymer particles’ production using a single microfluidic device

Benzion Amoyav, Ofra Benny*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Microfluidics technology offers a new platform to control liquids under flow in small volumes. The advantage of using small-scale reactions for droplet generation along with the capacity to control the preparation parameters, making microfluidic chips an attractive technology for optimizing encapsulation formulations. However, one of the drawback in this methodology is the ability to obtain a wide range of droplet sizes, from sub-micron to microns using a single chip design. In fact, typically, droplet chips are used for micron-dimension particles, while nanoparticles’ synthesis requires complex chips design (i.e., microreactors and staggered herringbone micromixer). Here, we introduce the development of a highly tunable and controlled encapsulation technique, using two polymer compositions, for generating particles ranging from microns to nano-size using the same simple single microfluidic chip design. Poly(lactic-co-glycolic acid) (PLGA 50:50) or PLGA/polyethylene glycol polymeric particles were prepared with focused-flow chip, yielding monodisperse particle batches. We show that by varying flow rate, solvent, surfactant and polymer composition, we were able to optimize particles’ size and decrease polydispersity index, using simple chip designs with no further related adjustments or costs. Utilizing this platform, which offers tight tuning of particle properties, could offer an important tool for formulation development and can potentially pave the way towards a better precision nanomedicine.

Original languageAmerican English
Pages (from-to)905-914
Number of pages10
JournalApplied Nanoscience (Switzerland)
Volume8
Issue number4
DOIs
StatePublished - 1 Apr 2018

Bibliographical note

Funding Information:
Acknowledgements We gratefully acknowledge the support from the Israel Science Foundation; Marie Curie CIG, and The Israeli Ministry of Science and Technology. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 756762) and Kamin fund from the Israeli Innovation Authority. We wish to thank Dr. Eduard Berenstein from the Core Research Facility of the Hebrew University for his help in the TEM and SEM studies. We also would like to thank Dr. Vitaly Gutkin from the Nano-center of the Hebrew University for his help in the SEM studies.

Funding Information:
We gratefully acknowledge the support from the Israel Science Foundation; Marie Curie CIG, and The Israeli Ministry of Science and Technology. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 756762) and Kamin fund from the Israeli Innovation Authority. We wish to thank Dr. Eduard Berenstein from the Core Research Facility of the Hebrew University for his help in the TEM and SEM studies. We also would like to thank Dr. Vitaly Gutkin from the Nano-center of the Hebrew University for his help in the SEM studies.

Publisher Copyright:
© 2018, The Author(s).

Keywords

  • Focused flow
  • Microfluidics
  • Microparticles
  • Nanoparticles
  • Polymeric particles

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