Abstract
Studying the internal structure of complex samples with light is an important task but a difficult challenge due to light scattering. While the complex optical distortions induced by scattering can be effectively undone if the medium’s scattering-matrix is known, this matrix generally cannot be retrieved without the presence of an invasive detector or guide-star at the target points of interest. To overcome this limitation, the current state-of-the-art approaches utilize focused ultrasound for generating acousto-optic guide-stars, in a variety of different techniques. Here, we introduce the acousto-optic transmission matrix (AOTM), which is an ultrasonically-encoded, spatially-resolved, optical scattering-matrix. The AOTM provides both a generalized framework to describe any acousto-optic based technique, and a tool for light control and focusing beyond the acoustic diffraction-limit inside complex samples. We experimentally demonstrate complex light control using the AOTM singular vectors, and utilize the AOTM framework to analyze the resolution limitation of acousto-optic guided focusing approaches.
| Original language | American English |
|---|---|
| Article number | 717 |
| Journal | Nature Communications |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Dec 2019 |
Bibliographical note
Funding Information:The authors thank Mingjun Chu and Paul Michael Petersen, Technical University of Denmark, for providing the long-coherence laser source, and Benjamin Judkewitz and Sebastien Popoff for helpful discussions. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grants no. 278025, 677909), and LABEX WIFI (Laboratory of Excellence within the French Program “Investments for the Future”) under references ANR-10-LABX-24. O.K. was supported by a Marie Curie intra-European fellowship (IEF) and an Azrieli Faculty Fellowship. S.G. acknowledge support from the Institut Universitaire de France (IUF).
Publisher Copyright:
© 2019, The Author(s).