Convergence along the visual hierarchy is altered in posterior cortical atrophy

Pieter B. De Best, Ruth Abulafia, Ayelet McKyton, Netta Levin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

PURPOSE. Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome manifesting with visuospatial processing impairment. We recently suggested that abnormal population receptive field properties are associated with the symptoms of PCA patients. Specifically, simultanagnosia, the inability to perceive multiple items simultaneously, can be explained by smaller peripheral population receptive fields, and foveal crowding, in which nearby distractors interfere with object perception, may result from larger foveal population receptive fields. These effects occurred predominantly in V1, even though atrophy mainly involves high-order areas. In this study, we used connective field modeling to better understand these inter-area interactions. METHODS. We used functional magnetic resonance imaging to scan six PCA patients and eight controls while they viewed drifting bar stimuli. Resting-state data were also collected. Connective field modeling was applied for both conditions: once when the source was V1 and the targets were extrastriate areas and once for the opposite direction. The difference between the two was defined as convergence magnitude. RESULTS. With stimulus, the convergence magnitude of the controls increased along the visual pathway, suggesting that spatial integration from V1 becomes larger up the visual hierarchy. No such slope was found in the PCA patients. The difference between the groups originated mainly from the dorsal pathway. Without stimulus, the convergence magnitude was negative, slightly more so for the PCA patients, with no slope, suggesting constant divergence along the visual hierarchy. CONCLUSIONS. Atrophy in one part of the visual system can affect other areas within the network through complex intervisual area interactions, resulting in modulation of population receptive field properties and an ensemble of visuocognitive function impairments.

Original languageAmerican English
Article number8
JournalInvestigative Ophthalmology and Visual Science
Volume61
Issue number11
DOIs
StatePublished - Sep 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Association for Research in Vision and Ophthalmology Inc.. All rights reserved.

Keywords

  • Complex visual problems
  • Connective field
  • FMRI
  • Foveal crowding
  • Posterior cortical atrophy
  • Simultanagnosia

Fingerprint

Dive into the research topics of 'Convergence along the visual hierarchy is altered in posterior cortical atrophy'. Together they form a unique fingerprint.

Cite this