Coordination of transcription and processing of tRNA

Nayef Jarrous*, Dhivakar Mani, Aravind Ramanathan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Coordination of transcription and processing of RNA is a basic principle in regulation of gene expression in eukaryotes. In the case of mRNA, coordination is primarily founded on a co-transcriptional processing mechanism by which a nascent precursor mRNA undergoes maturation via cleavage and modification by the transcription machinery. A similar mechanism controls the biosynthesis of rRNA. However, the coordination of transcription and processing of tRNA, a rather short transcript, remains unknown. Here, we present a model for high molecular weight initiation complexes of human RNA polymerase III that assemble on tRNA genes and process precursor transcripts to mature forms. These multifunctional initiation complexes may support co-transcriptional processing, such as the removal of the 5’ leader of precursor tRNA by RNase P. Based on this model, maturation of tRNA is predetermined prior to transcription initiation.

Original languageAmerican English
Pages (from-to)3630-3641
Number of pages12
JournalFEBS Journal
Issue number13
StatePublished - Jul 2022

Bibliographical note

Publisher Copyright:
© 2021 Federation of European Biochemical Societies.


  • RNA polymerase III
  • RNase P
  • RNase Z
  • tRNA
  • tRNA splicing complex


Dive into the research topics of 'Coordination of transcription and processing of tRNA'. Together they form a unique fingerprint.

Cite this