TY - JOUR
T1 - Copolymers of pharmaceutical grade lactic acid and sebacic acid
T2 - Drug release behavior and biocompatibility
AU - Modi, Sweta
AU - Jain, Jay Prakash
AU - Domb, A. J.
AU - Kumar, Neeraj
PY - 2006/11
Y1 - 2006/11
N2 - Pharmaceutical grade d,l-lactic acid, which is rather an economic source in comparison to lactide monomer, was utilized for synthesis of a series of copolymers with sebacic acid. Polymers were characterized by GPC, FTIR, NMR and DSC techniques, and formulated into blank and methotrexate (MTX) loaded microspheres by emulsion-solvent evaporation method. In vitro degradation of blank microspheres was studied by FTIR, GPC and SEM analysis. MTX loaded microspheres showed the encapsulation efficiency of 44-64% and were in the size range of 40-60 μm. These were used to study the release profile of the encapsulated drug. The release was found to be affected by the pH and buffer concentration of the release medium which was in turn revealed by solubility studies of MTX. The overall study demonstrates significance of drug as well as polymer properties on release. Biocompatibility of polymer was evaluated by injecting microspheres subcutaneously into Sprague-Dawley (SD) rat and no local histopathological abnormalities were found.
AB - Pharmaceutical grade d,l-lactic acid, which is rather an economic source in comparison to lactide monomer, was utilized for synthesis of a series of copolymers with sebacic acid. Polymers were characterized by GPC, FTIR, NMR and DSC techniques, and formulated into blank and methotrexate (MTX) loaded microspheres by emulsion-solvent evaporation method. In vitro degradation of blank microspheres was studied by FTIR, GPC and SEM analysis. MTX loaded microspheres showed the encapsulation efficiency of 44-64% and were in the size range of 40-60 μm. These were used to study the release profile of the encapsulated drug. The release was found to be affected by the pH and buffer concentration of the release medium which was in turn revealed by solubility studies of MTX. The overall study demonstrates significance of drug as well as polymer properties on release. Biocompatibility of polymer was evaluated by injecting microspheres subcutaneously into Sprague-Dawley (SD) rat and no local histopathological abnormalities were found.
KW - Biocompatibility
KW - Biodegradable polymers
KW - Drug delivery
KW - Drug release kinetics
KW - Microspheres
KW - PLA-PSA
KW - Profile modeling
UR - http://www.scopus.com/inward/record.url?scp=33750048145&partnerID=8YFLogxK
U2 - 10.1016/j.ejpb.2006.05.013
DO - 10.1016/j.ejpb.2006.05.013
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C2 - 16846724
AN - SCOPUS:33750048145
SN - 0939-6411
VL - 64
SP - 277
EP - 286
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
IS - 3
ER -