Copper-Mediated Selenazolidine Deprotection Enables One-Pot Chemical Synthesis of Challenging Proteins

Keyphrases

• Copper-mediated 100%
• Selenazolidine 100%
• Chemical Synthesis 100%
• Synthetic Approaches 100%
• Deprotection 100%
• Catalytic Activity 50%
• Thiosulfate 50%
• Native Chemical Ligation 50%
• Chemical Protein Synthesis 50%
• Glutathione 50%
• Kinetically Controlled Ligation 50%
• Active Sites 50%
• Deselenization 50%
• Total Synthesis 50%
• Selenocysteine 50%
• Selenoprotein 50%
• Chemoselective 50%
• Low Abundance 50%
• Low Activity 50%
• Cysteine Residues 50%
• Sulfurtransferase 50%
• Cysteine 50%
• Strategic Placement 50%
• Cu(II) 50%
• Non-strategic 50%

Biochemistry, Genetics and Molecular Biology

• Synthesis 100%
• Cysteine 100%
• Thiosulfate 50%
• Selenoprotein 50%
• Selenocysteine 50%
• Native Chemical Ligation 50%
• Protein Biosynthesis 50%
• Isolation and Purification 50%
• Active Site 50%
• Enzymatic Activity 50%
• Glutathione 50%

Chemistry

• Cysteine 100%
• Protein Synthesis 50%
• Selenocysteine 50%
• Thiosulfate 50%
• Chemoselectivity 50%
• Catalyst Activity 50%
• Glutathione 50%