Abstract
In vitro the corneal endothelial fluid pump's survival is improved by enzymes which counteract the deleterious effect of free radicals created during the surgery-anoxia-cooling period. This model behaves similarly to other tissues. One of the minor theories attributes cellular aging to the damage due to free radicals. It is suggested, therefore, that the corneal endothelial fluid pump preparation might be a model to screen antioxidants in order to find more efficient agents to prolong cellular survival. The basic question, however, is why the essentially non-dividing endothelial cells in vivo are able to function - for at least two lifetimes - whereas in vitro, in spite of all our efforts, the maximum survival is only about 15 hours.
| Original language | English |
|---|---|
| Pages (from-to) | 629-634 |
| Number of pages | 6 |
| Journal | Atti della Fondazione Giorgio Ronchi |
| Volume | 40 |
| Issue number | 5-6 |
| State | Published - 1985 |