TY - JOUR
T1 - Corrigendum
T2 - Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells (Frontiers in Immunology, (2023), 14, (1170821), 10.3389/fimmu.2023.1170821)
AU - Kunkl, Martina
AU - Amormino, Carola
AU - Spallotta, Francesco
AU - Caristi, Silvana
AU - Fiorillo, Maria Teresa
AU - Paiardini, Alessandro
AU - Kaempfer, Raymond
AU - Tuosto, Loretta
N1 - Publisher Copyright:
Copyright © 2023 Kunkl, Amormino, Spallotta, Caristi, Fiorillo, Paiardini, Kaempfer and Tuosto.
PY - 2023
Y1 - 2023
N2 - In the published article, there was an error in Figure 3 as published. Figure 3 was substituted with Figure 4, which was duplicated. The corrected Figure 3 and its caption appear below. Stimulation of CD4+ T cells by SEB induces the secretion of inflammatory cytokines in the absence of MHC class II- and B7-expressing APCs. (A–G) Human CD4+ T cells isolated by the peripheral blood of healthy donors (HD) were unstimulated (Med) or stimulated for different times with 1 μg ml-1 SEB. IFN-γ (A), IL-2 (B), IL-6 (C), TNF-α (D), IL-17A (E), IL-22 (F) and GM-CSF (G) levels in culture supernatant were measured by ELISA. Data show the mean ± SEM of different HD (n = 4). Statistical significance was calculated by One-way ANOVA. Means values (pg ml-1): 24 hours; IFN-γ, Med = 0, SEB = 328.7; IL-2, Med = 0, SEB = 1966; IL-6, Med = 92.2; SEB = 249; TNF-α, Med = 0, SEB = 1959; IL-17A, Med = 0, SEB = 251.7; IL-22, Med = 37.4, SEB = 1197; GM-CSF, Med = 19.1, SEB = 916.5. 48 hours; IFN-γ, Med = 0, SEB = 1738; IL-2, Med = 0, SEB = 2600; IL-6, Med = 96.7, SEB = 498.8; TNF-α, Med = 0, SEB = 3361; IL-17A, Med = 0, SEB = 1884; IL-22, Med = 178.6, SEB = 5726; GM-CSF, Med = 22,3, SEB = 3426. 72 hours; IFN-γ, Med = 0, SEB = 3099; IL-2, Med = 0.9, SEB = 2303; IL-6, Med = 95, SEB = 851.5; TNF-α, Med = 2.6, SEB = 3591; IL-17A, Med = 0, SEB = 4211; IL-22, Med = 140.9, SEB = 10737; GM-CSF, Med = 42.3, SEB = 7633. (*) p < 0.05, (**) p < 0.01, (***) p < 0.001, (****) p < 0.0001. NS, not significant. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
AB - In the published article, there was an error in Figure 3 as published. Figure 3 was substituted with Figure 4, which was duplicated. The corrected Figure 3 and its caption appear below. Stimulation of CD4+ T cells by SEB induces the secretion of inflammatory cytokines in the absence of MHC class II- and B7-expressing APCs. (A–G) Human CD4+ T cells isolated by the peripheral blood of healthy donors (HD) were unstimulated (Med) or stimulated for different times with 1 μg ml-1 SEB. IFN-γ (A), IL-2 (B), IL-6 (C), TNF-α (D), IL-17A (E), IL-22 (F) and GM-CSF (G) levels in culture supernatant were measured by ELISA. Data show the mean ± SEM of different HD (n = 4). Statistical significance was calculated by One-way ANOVA. Means values (pg ml-1): 24 hours; IFN-γ, Med = 0, SEB = 328.7; IL-2, Med = 0, SEB = 1966; IL-6, Med = 92.2; SEB = 249; TNF-α, Med = 0, SEB = 1959; IL-17A, Med = 0, SEB = 251.7; IL-22, Med = 37.4, SEB = 1197; GM-CSF, Med = 19.1, SEB = 916.5. 48 hours; IFN-γ, Med = 0, SEB = 1738; IL-2, Med = 0, SEB = 2600; IL-6, Med = 96.7, SEB = 498.8; TNF-α, Med = 0, SEB = 3361; IL-17A, Med = 0, SEB = 1884; IL-22, Med = 178.6, SEB = 5726; GM-CSF, Med = 22,3, SEB = 3426. 72 hours; IFN-γ, Med = 0, SEB = 3099; IL-2, Med = 0.9, SEB = 2303; IL-6, Med = 95, SEB = 851.5; TNF-α, Med = 2.6, SEB = 3591; IL-17A, Med = 0, SEB = 4211; IL-22, Med = 140.9, SEB = 10737; GM-CSF, Med = 42.3, SEB = 7633. (*) p < 0.05, (**) p < 0.01, (***) p < 0.001, (****) p < 0.0001. NS, not significant. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
KW - CD28
KW - inflammation
KW - staphylococcal superantigens
KW - T cells
KW - TCR (T cell receptor)
UR - http://www.scopus.com/inward/record.url?scp=85169294980&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2023.1273921
DO - 10.3389/fimmu.2023.1273921
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C2 - 37654481
AN - SCOPUS:85169294980
SN - 1664-3224
VL - 14
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1273921
ER -