TY - JOUR
T1 - Cortical circuits modulate mouse social vocalizations
AU - Gan-Or, Benjamin
AU - London, Michael
N1 - Publisher Copyright:
Copyright © 2023 The Authors, some rights reserved.
PY - 2023/9/29
Y1 - 2023/9/29
N2 - Vocalizations provide a means of communication with high fidelity and information rate for many species. Di-encephalon and brainstem neural circuits have been shown to control mouse vocal production; however, the role of cortical circuits in this process is debatable. Using electrical and optogenetic stimulation, we identified a cortical region in the anterior cingulate cortex in which stimulation elicits ultrasonic vocalizations. Moreover, fiber photometry showed an increase in Ca2+ dynamics preceding vocal initiation, whereas optogenetic suppression in this cortical area caused mice to emit fewer vocalizations. Last, electrophysiological recordings indicated a differential increase in neural activity in response to female social exposure dependent on vocal output. Together, these results indicate that the cortex is a key node in the neuronal circuits controlling vocal behavior in mice.
AB - Vocalizations provide a means of communication with high fidelity and information rate for many species. Di-encephalon and brainstem neural circuits have been shown to control mouse vocal production; however, the role of cortical circuits in this process is debatable. Using electrical and optogenetic stimulation, we identified a cortical region in the anterior cingulate cortex in which stimulation elicits ultrasonic vocalizations. Moreover, fiber photometry showed an increase in Ca2+ dynamics preceding vocal initiation, whereas optogenetic suppression in this cortical area caused mice to emit fewer vocalizations. Last, electrophysiological recordings indicated a differential increase in neural activity in response to female social exposure dependent on vocal output. Together, these results indicate that the cortex is a key node in the neuronal circuits controlling vocal behavior in mice.
UR - http://www.scopus.com/inward/record.url?scp=85172829779&partnerID=8YFLogxK
U2 - 10.1126/SCIADV.ADE6992
DO - 10.1126/SCIADV.ADE6992
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C2 - 37774030
AN - SCOPUS:85172829779
SN - 2375-2548
VL - 9
JO - Science advances
JF - Science advances
IS - 39
M1 - eade6992
ER -