Corticobasal syndrome with visual hallucinations and probable REM-sleep behavior disorder: an autopsied case report of a patient with CBD and LBD pathology

George Naasan*, Tal Shany-Ur, Manu Sidhu, Cynthia Barton, Robin Ketelle, Suzanne M. Shdo, Joel H. Kramer, Bruce L. Miller, William W. Seeley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Corticobasal syndrome and dementia with Lewy bodies are clinical presentations with unique and overlapping features but distinct pathological substrates. We report the case of an 80 year-old man who presented with apraxia, rigidity, slowness, right arm myoclonus, a 10-year history of probable REM-sleep behavior disorder, and later developed visual hallucinations. At autopsy, he had pathological features of corticobasal degeneration, and Lewy body disease confined to the brainstem. This report highlights the importance of considering co-existing pathologies when a clinical presentation defies categorization, and demonstrates that salient features of dementia with Lewy bodies may result from pathology limited to the brainstem.

Original languageAmerican English
Pages (from-to)26-33
Number of pages8
JournalNeurocase
Volume25
Issue number1-2
DOIs
StatePublished - 4 Mar 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Corticobasal syndrome
  • corticobasal degeneration
  • dementia with Lewy body disease
  • pathology
  • tau
  • α-synuclein

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