Cranberry components for the therapy of infectious disease

Haim Shmuely, Itzhak Ofek*, Ervin I. Weiss, Zichria Rones, Yael Houri-Haddad

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Summary of the in vitro data support a beneficial effect of cranberry or its proanthocyanin constituents by blocking adhesion to and biofilm formation on target tissues of pathogens. In vivo data partially support these beneficial effects. Consumption of various cranberry products benefited young and elderly females in preventing urinary tract infections, and in conjunction with antibiotic treatment in eradicating Helicobacter pylori infections in women. Mouthwash supplemented with an isolated cranberry derivative reduced significantly the caryogenic mutans streptococci. None of the mice infected intranasal with lethal dose of influenza virus and treated with cranberry fraction died after two weeks. Further studies should focus on the active cranberry component as supplement for food and other products especially where whole juice or powder cannot be used.

Original languageAmerican English
Pages (from-to)148-152
Number of pages5
JournalCurrent Opinion in Biotechnology
Volume23
Issue number2
DOIs
StatePublished - Apr 2012
Externally publishedYes

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