TY - JOUR
T1 - Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders
AU - Brennand, Kristen J.
AU - Marchetto, M. Carol
AU - Benvenisty, Nissim
AU - Brüstle, Oliver
AU - Ebert, Allison
AU - Izpisua Belmonte, Juan Carlos
AU - Kaykas, Ajamete
AU - Lancaster, Madeline A.
AU - Livesey, Frederick J.
AU - McConnell, Michael J.
AU - McKay, Ronald D.
AU - Morrow, Eric M.
AU - Muotri, Alysson R.
AU - Panchision, David M.
AU - Rubin, Lee L.
AU - Sawa, Akira
AU - Soldner, Frank
AU - Song, Hongjun
AU - Studer, Lorenz
AU - Temple, Sally
AU - Vaccarino, Flora M.
AU - Wu, Jun
AU - Vanderhaeghen, Pierre
AU - Gage, Fred H.
AU - Jaenisch, Rudolf
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015/12/8
Y1 - 2015/12/8
N2 - As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.
AB - As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.
UR - http://www.scopus.com/inward/record.url?scp=84949526040&partnerID=8YFLogxK
U2 - 10.1016/j.stemcr.2015.10.011
DO - 10.1016/j.stemcr.2015.10.011
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C2 - 26610635
AN - SCOPUS:84949526040
SN - 2213-6711
VL - 5
SP - 933
EP - 945
JO - Stem Cell Reports
JF - Stem Cell Reports
IS - 6
ER -