Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders

Kristen J. Brennand; M. Carol Marchetto; Nissim Benvenisty; Oliver Brüstle; Allison Ebert; Juan Carlos Izpisua Belmonte; Ajamete Kaykas; Madeline A. Lancaster; Frederick J. Livesey; Michael J. McConnell; Ronald D. McKay; Eric M. Morrow; Alysson R. Muotri; David M. Panchision; Lee L. Rubin; Akira Sawa; Frank Soldner; Hongjun Song; Lorenz Studer; Sally Temple; Flora M. Vaccarino; Jun Wu; Pierre Vanderhaeghen; Fred H. Gage; Rudolf Jaenisch

doi:10.1016/j.stemcr.2015.10.011

Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders

Kristen J. Brennand, M. Carol Marchetto, Nissim Benvenisty, Oliver Brüstle, Allison Ebert, Juan Carlos Izpisua Belmonte, Ajamete Kaykas, Madeline A. Lancaster, Frederick J. Livesey, Michael J. McConnell, Ronald D. McKay, Eric M. Morrow, Alysson R. Muotri, David M. Panchision, Lee L. Rubin, Akira Sawa, Frank Soldner, Hongjun Song, Lorenz Studer, Sally TempleFlora M. Vaccarino, Jun Wu, Pierre Vanderhaeghen, Fred H. Gage^*, Rudolf Jaenisch

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.

Original language	English
Pages (from-to)	933-945
Number of pages	13
Journal	Stem Cell Reports
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/j.stemcr.2015.10.011
State	Published - 8 Dec 2015

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Publisher Copyright:
© 2015 The Authors.

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Brennand, K. J., Marchetto, M. C., Benvenisty, N., Brüstle, O., Ebert, A., Izpisua Belmonte, J. C., Kaykas, A., Lancaster, M. A., Livesey, F. J., McConnell, M. J., McKay, R. D., Morrow, E. M., Muotri, A. R., Panchision, D. M., Rubin, L. L., Sawa, A., Soldner, F., Song, H., Studer, L., ... Jaenisch, R. (2015). Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders. Stem Cell Reports, 5(6), 933-945. https://doi.org/10.1016/j.stemcr.2015.10.011

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abstract = "As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.",

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doi = "10.1016/j.stemcr.2015.10.011",

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Brennand, KJ, Marchetto, MC, Benvenisty, N, Brüstle, O, Ebert, A, Izpisua Belmonte, JC, Kaykas, A, Lancaster, MA, Livesey, FJ, McConnell, MJ, McKay, RD, Morrow, EM, Muotri, AR, Panchision, DM, Rubin, LL, Sawa, A, Soldner, F, Song, H, Studer, L, Temple, S, Vaccarino, FM, Wu, J, Vanderhaeghen, P, Gage, FH & Jaenisch, R 2015, 'Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders', Stem Cell Reports, vol. 5, no. 6, pp. 933-945. https://doi.org/10.1016/j.stemcr.2015.10.011

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AU - Marchetto, M. Carol

AU - Benvenisty, Nissim

AU - Brüstle, Oliver

AU - Ebert, Allison

AU - Izpisua Belmonte, Juan Carlos

AU - Kaykas, Ajamete

AU - Lancaster, Madeline A.

AU - Livesey, Frederick J.

AU - McConnell, Michael J.

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AU - Morrow, Eric M.

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AU - Soldner, Frank

AU - Song, Hongjun

AU - Studer, Lorenz

AU - Temple, Sally

AU - Vaccarino, Flora M.

AU - Wu, Jun

AU - Vanderhaeghen, Pierre

AU - Gage, Fred H.

AU - Jaenisch, Rudolf

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Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders

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