TY - JOUR
T1 - Critical Points in Tumorigenesis
T2 - A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics
AU - Poovathingal, Suresh Kumar
AU - Kravchenko-Balasha, Nataly
AU - Shin, Young Shik
AU - Levine, Raphael David
AU - Heath, James R.
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2016/3/16
Y1 - 2016/3/16
N2 - A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.
AB - A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.
KW - carcinogenesis
KW - microfluidics
KW - phase transition
KW - single-cell proteomics
KW - steady state
UR - http://www.scopus.com/inward/record.url?scp=84960372123&partnerID=8YFLogxK
U2 - 10.1002/smll.201501178
DO - 10.1002/smll.201501178
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C2 - 26780498
AN - SCOPUS:84960372123
SN - 1613-6810
VL - 12
SP - 1425
EP - 1431
JO - Small
JF - Small
IS - 11
ER -