Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics

Suresh Kumar Poovathingal, Nataly Kravchenko-Balasha, Young Shik Shin, Raphael David Levine, James R. Heath*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.

Original languageAmerican English
Pages (from-to)1425-1431
Number of pages7
JournalSmall
Volume12
Issue number11
DOIs
StatePublished - 16 Mar 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

  • carcinogenesis
  • microfluidics
  • phase transition
  • single-cell proteomics
  • steady state

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