Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics

Suresh Kumar Poovathingal; Nataly Kravchenko-Balasha; Young Shik Shin; Raphael David Levine; James R. Heath

doi:10.1002/smll.201501178

Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics

Suresh Kumar Poovathingal
, Nataly Kravchenko-Balasha
, Young Shik Shin
, Raphael David Levine
, James R. Heath^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.

Original language	English
Pages (from-to)	1425-1431
Number of pages	7
Journal	Small
Volume	12
Issue number	11
DOIs	https://doi.org/10.1002/smll.201501178
State	Published - 16 Mar 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

carcinogenesis
microfluidics
phase transition
single-cell proteomics
steady state

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10.1002/smll.201501178

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abstract = "A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.",

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AU - Shin, Young Shik

AU - Levine, Raphael David

AU - Heath, James R.

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KW - microfluidics

KW - phase transition

KW - single-cell proteomics

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Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics

Abstract

Bibliographical note

Keywords

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