Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

Keyphrases

• Murine Double Minute 2 (MDM2) 100%
• Negative Regulation 100%
• Phosphorylation 33%
• P53 Stabilization 22%
• P53 Activity 22%
• DNA Damage 11%
• Inhibitory Effect 11%
• Wild-type p53 11%
• In Vitro Binding 11%
• Environmental Stress 11%
• Transcriptional Activation 11%
• Phosphorylation Sites 11%
• Cell Growth 11%
• Feedback Loop 11%
• Phosphoprotein 11%
• Oncoprotein 11%
• Double Minutes 11%
• Apoptosis Activation 11%
• P53 Regulation 11%
• MDM2-p53 Interaction 11%

Biochemistry, Genetics and Molecular Biology

• P53 100%
• Mdm2 100%
• N-Terminus 5%
• Transactivation 5%
• Wild Type 5%
• Environmental Stress 5%
• Transcription Initiation 5%
• DNA Damage Response 5%
• Cell Growth 5%
• Serine 5%

Neuroscience

• P53 100%
• In Vivo 16%
• Amino Terminal Sequence 5%
• In Vitro 5%
• Serine 5%
• Transcription Initiation 5%
• Cell Growth 5%
• DNA Damage Response 5%
• Oncoprotein 5%
• Transactivation 5%
• Double Minute 5%