TY - JOUR
T1 - Cross-excitation in dorsal root ganglia does not depend on close cell- to-cell apposition
AU - Shinder, Vera
AU - Amir, Ron
AU - Devor, Marshall
PY - 1998/12/21
Y1 - 1998/12/21
N2 - About 90% of neurons in dorsal root ganglia (DRGs) of rats 2-5 weeks of age are depolarized and excited by impulse activity in neighboring neurons that share the same DRG. Synaptic contacts are extremely rare in DRGs, but instances of close membrane apposition between pairs of neuronal somata are not uncommon, especially in prenatal rats. Close membrane apposition could permit electrotonic interactions among neighboring DRG neurons. We carried out an ultrastructural examination of DRGs taken from rats 2-5 weeks of age and found that by this age < 2% of cells remain in close apposition with neighbors. The remainder are separated by one or two layers of satellite glial cytoplasm. It is, therefore, unlikely that close apposition between adjacent neurons contributes significantly to functional cross-excitation in the DRG.
AB - About 90% of neurons in dorsal root ganglia (DRGs) of rats 2-5 weeks of age are depolarized and excited by impulse activity in neighboring neurons that share the same DRG. Synaptic contacts are extremely rare in DRGs, but instances of close membrane apposition between pairs of neuronal somata are not uncommon, especially in prenatal rats. Close membrane apposition could permit electrotonic interactions among neighboring DRG neurons. We carried out an ultrastructural examination of DRGs taken from rats 2-5 weeks of age and found that by this age < 2% of cells remain in close apposition with neighbors. The remainder are separated by one or two layers of satellite glial cytoplasm. It is, therefore, unlikely that close apposition between adjacent neurons contributes significantly to functional cross-excitation in the DRG.
KW - Close appositions
KW - Crosstalk
KW - Dorsal root ganglion
KW - Satellite cell sheath
UR - http://www.scopus.com/inward/record.url?scp=0032556732&partnerID=8YFLogxK
U2 - 10.1097/00001756-199812210-00002
DO - 10.1097/00001756-199812210-00002
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C2 - 9926836
AN - SCOPUS:0032556732
SN - 0959-4965
VL - 9
SP - 3997
EP - 4000
JO - NeuroReport
JF - NeuroReport
IS - 18
ER -