TY - JOUR
T1 - Cross-linked chondroitin sulphate
T2 - characterization for drug delivery purposes
AU - Sintov, Amnon
AU - Di-Capua, Noam
AU - Rubinstein, Abraham
PY - 1995
Y1 - 1995
N2 - Chondroitin sulphate was cross-linked with 1,12-diaminododecane to give a series of cross-linked products with reduced water solubility. Since the water solubility of the modified polymers is low, their chemical characterization is complicated. A new method based on the adsorption of the cationic dye, methylene blue, on the cross-linked polymers was developed to characterize the degree of cross-linking. It was found that the values of the adsorptive capacity of the adsorbate, Cp(s), decreased with the extent of cross-linking. However, the values of the adsorptive coefficient, K, and the free energy change of the adsorption reaction, Δμ °, increased with cross-linking. The swelling of films made of the cross-linked polymers was measured in water and an exponential-like dependency between the degree of swelling and extent of cross-linking could be defined. Indomethacin tablets made of two types of cross-linked polymers - very low water soluble and relatively high water soluble - were made and analysed for their water uptake and drug release characteristics. Based on the physicochemical properties, an optimal product with a potential to serve as a colon-specific drug carrier was suggested.
AB - Chondroitin sulphate was cross-linked with 1,12-diaminododecane to give a series of cross-linked products with reduced water solubility. Since the water solubility of the modified polymers is low, their chemical characterization is complicated. A new method based on the adsorption of the cationic dye, methylene blue, on the cross-linked polymers was developed to characterize the degree of cross-linking. It was found that the values of the adsorptive capacity of the adsorbate, Cp(s), decreased with the extent of cross-linking. However, the values of the adsorptive coefficient, K, and the free energy change of the adsorption reaction, Δμ °, increased with cross-linking. The swelling of films made of the cross-linked polymers was measured in water and an exponential-like dependency between the degree of swelling and extent of cross-linking could be defined. Indomethacin tablets made of two types of cross-linked polymers - very low water soluble and relatively high water soluble - were made and analysed for their water uptake and drug release characteristics. Based on the physicochemical properties, an optimal product with a potential to serve as a colon-specific drug carrier was suggested.
KW - adsorption isotherms
KW - chondroitin sulphate
KW - colon-specific drug delivery
KW - cross-linked polymers
KW - Drug delivery
KW - indomethacin
KW - pH-dependent swelling
UR - http://www.scopus.com/inward/record.url?scp=0029278168&partnerID=8YFLogxK
U2 - 10.1016/0142-9612(95)98820-5
DO - 10.1016/0142-9612(95)98820-5
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 7654874
AN - SCOPUS:0029278168
SN - 0142-9612
VL - 16
SP - 473
EP - 478
JO - Biomaterials
JF - Biomaterials
IS - 6
ER -