Crosslinked QA-PEI nanoparticles: Synthesis reproducibility, chemical modifications, and stability study

Shady Farah; Wahid Khan; Ira Farber; Dana Kesler-Shvero; Nurit Beyth; Ervin I. Weiss; Abraham J. Domb

doi:10.1002/pat.3102

Crosslinked QA-PEI nanoparticles: Synthesis reproducibility, chemical modifications, and stability study

Shady Farah, Wahid Khan, Ira Farber, Dana Kesler-Shvero, Nurit Beyth, Ervin I. Weiss, Abraham J. Domb^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Quaternary ammonium polyethylenimine (QA-PEI) nanoparticles were synthesized by PEI crosslinking and alkylation with octyliodide followed by quaternization by methyl iodide. The present study focuses on the reproducibility of particles formation with respect to particle size, positive charge, oxidative, thermal stability and antibacterial activity. The QA-PEI-based nanoparticles with particle size in the range of 160-190nm were synthesized in high reproducibility and showed high chemical stability against environmental changes including exposure to different oxidizers and storage conditions. QA-PEI nanoparticles incorporated in dental restorative resin composites at 2% w/w demonstrated strong antibacterial activity.

Original language	English
Pages (from-to)	446-452
Number of pages	7
Journal	Polymers for Advanced Technologies
Volume	24
Issue number	5
DOIs	https://doi.org/10.1002/pat.3102
State	Published - May 2013

Keywords

Antimicrobial dental composite
Antimicrobial surface
Nanoparticles
Polyethylenimine

Access to Document

10.1002/pat.3102

Cite this

@article{d64887084e0546fd89fb3acc2b6159ee,

title = "Crosslinked QA-PEI nanoparticles: Synthesis reproducibility, chemical modifications, and stability study",

abstract = "Quaternary ammonium polyethylenimine (QA-PEI) nanoparticles were synthesized by PEI crosslinking and alkylation with octyliodide followed by quaternization by methyl iodide. The present study focuses on the reproducibility of particles formation with respect to particle size, positive charge, oxidative, thermal stability and antibacterial activity. The QA-PEI-based nanoparticles with particle size in the range of 160-190nm were synthesized in high reproducibility and showed high chemical stability against environmental changes including exposure to different oxidizers and storage conditions. QA-PEI nanoparticles incorporated in dental restorative resin composites at 2% w/w demonstrated strong antibacterial activity.",

keywords = "Antimicrobial dental composite, Antimicrobial surface, Nanoparticles, Polyethylenimine",

author = "Shady Farah and Wahid Khan and Ira Farber and Dana Kesler-Shvero and Nurit Beyth and Weiss, {Ervin I.} and Domb, {Abraham J.}",

year = "2013",

month = may,

doi = "10.1002/pat.3102",

language = "אנגלית",

volume = "24",

pages = "446--452",

journal = "Polymers for Advanced Technologies",

issn = "1042-7147",

publisher = "John Wiley and Sons Ltd",

number = "5",

}

TY - JOUR

T1 - Crosslinked QA-PEI nanoparticles

T2 - Synthesis reproducibility, chemical modifications, and stability study

AU - Farah, Shady

AU - Khan, Wahid

AU - Farber, Ira

AU - Kesler-Shvero, Dana

AU - Beyth, Nurit

AU - Weiss, Ervin I.

AU - Domb, Abraham J.

PY - 2013/5

Y1 - 2013/5

N2 - Quaternary ammonium polyethylenimine (QA-PEI) nanoparticles were synthesized by PEI crosslinking and alkylation with octyliodide followed by quaternization by methyl iodide. The present study focuses on the reproducibility of particles formation with respect to particle size, positive charge, oxidative, thermal stability and antibacterial activity. The QA-PEI-based nanoparticles with particle size in the range of 160-190nm were synthesized in high reproducibility and showed high chemical stability against environmental changes including exposure to different oxidizers and storage conditions. QA-PEI nanoparticles incorporated in dental restorative resin composites at 2% w/w demonstrated strong antibacterial activity.

AB - Quaternary ammonium polyethylenimine (QA-PEI) nanoparticles were synthesized by PEI crosslinking and alkylation with octyliodide followed by quaternization by methyl iodide. The present study focuses on the reproducibility of particles formation with respect to particle size, positive charge, oxidative, thermal stability and antibacterial activity. The QA-PEI-based nanoparticles with particle size in the range of 160-190nm were synthesized in high reproducibility and showed high chemical stability against environmental changes including exposure to different oxidizers and storage conditions. QA-PEI nanoparticles incorporated in dental restorative resin composites at 2% w/w demonstrated strong antibacterial activity.

KW - Antimicrobial dental composite

KW - Antimicrobial surface

KW - Nanoparticles

KW - Polyethylenimine

UR - http://www.scopus.com/inward/record.url?scp=84876426165&partnerID=8YFLogxK

U2 - 10.1002/pat.3102

DO - 10.1002/pat.3102

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:84876426165

SN - 1042-7147

VL - 24

SP - 446

EP - 452

JO - Polymers for Advanced Technologies

JF - Polymers for Advanced Technologies

IS - 5

ER -

Crosslinked QA-PEI nanoparticles: Synthesis reproducibility, chemical modifications, and stability study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this