Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE

P. Hasson*, Z. Paroush

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

55 Scopus citations

Abstract

In this minireview, we briefly revisit the Drosophila Notch and epidermal growth factor receptor pathways, and relate to the relationship between them. We then mainly focus on the involvement of Groucho (Gro)/TLE, a global developmental corepressor, in these pathways. In particular, we discuss Gro/TLE's role at the junction between these two signal transduction cascades.

Original languageAmerican English
Pages (from-to)771-775
Number of pages5
JournalBritish Journal of Cancer
Volume94
Issue number6
DOIs
StatePublished - 27 Mar 2006

Bibliographical note

Funding Information:
We thank our following colleagues for fruitful discussions and for valuable comments on the manuscript: Howard Cedar, Einat Cinnamon, Oded Meyuhas, Benny Shilo and Joel Yisraeli. We apologise to our many colleagues for the incomplete referencing due to rigid space constraints. Work in our laboratory is supported by Grants from the Israel Science Foundation, Israel Cancer Research Fund and the Król Charitable Foundation. PH is an EMBO Long-Term Postdoctoral Fellow and ZP a Braun Lecturer.

Keywords

  • EGFR
  • Groucho/TLE
  • Notch
  • Signal transduction
  • Transcriptional regulation

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