Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE

P. Hasson; Z. Paroush

doi:10.1038/sj.bjc.6603019

Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE

P. Hasson^*, Z. Paroush

^*Corresponding author for this work

Department of Developmental Biology and Cancer Research

Research output: Contribution to journal › Short survey › peer-review

55 Scopus citations

Abstract

In this minireview, we briefly revisit the Drosophila Notch and epidermal growth factor receptor pathways, and relate to the relationship between them. We then mainly focus on the involvement of Groucho (Gro)/TLE, a global developmental corepressor, in these pathways. In particular, we discuss Gro/TLE's role at the junction between these two signal transduction cascades.

Original language	English
Pages (from-to)	771-775
Number of pages	5
Journal	British Journal of Cancer
Volume	94
Issue number	6
DOIs	https://doi.org/10.1038/sj.bjc.6603019
State	Published - 27 Mar 2006

Bibliographical note

Funding Information:
We thank our following colleagues for fruitful discussions and for valuable comments on the manuscript: Howard Cedar, Einat Cinnamon, Oded Meyuhas, Benny Shilo and Joel Yisraeli. We apologise to our many colleagues for the incomplete referencing due to rigid space constraints. Work in our laboratory is supported by Grants from the Israel Science Foundation, Israel Cancer Research Fund and the Król Charitable Foundation. PH is an EMBO Long-Term Postdoctoral Fellow and ZP a Braun Lecturer.

Keywords

EGFR
Groucho/TLE
Notch
Signal transduction
Transcriptional regulation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6603019

Cite this

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abstract = "In this minireview, we briefly revisit the Drosophila Notch and epidermal growth factor receptor pathways, and relate to the relationship between them. We then mainly focus on the involvement of Groucho (Gro)/TLE, a global developmental corepressor, in these pathways. In particular, we discuss Gro/TLE's role at the junction between these two signal transduction cascades.",

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Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE

Abstract

Bibliographical note

Keywords

UN SDGs

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