Abstract
In this minireview, we briefly revisit the Drosophila Notch and epidermal growth factor receptor pathways, and relate to the relationship between them. We then mainly focus on the involvement of Groucho (Gro)/TLE, a global developmental corepressor, in these pathways. In particular, we discuss Gro/TLE's role at the junction between these two signal transduction cascades.
| Original language | English |
|---|---|
| Pages (from-to) | 771-775 |
| Number of pages | 5 |
| Journal | British Journal of Cancer |
| Volume | 94 |
| Issue number | 6 |
| DOIs | |
| State | Published - 27 Mar 2006 |
Bibliographical note
Funding Information:We thank our following colleagues for fruitful discussions and for valuable comments on the manuscript: Howard Cedar, Einat Cinnamon, Oded Meyuhas, Benny Shilo and Joel Yisraeli. We apologise to our many colleagues for the incomplete referencing due to rigid space constraints. Work in our laboratory is supported by Grants from the Israel Science Foundation, Israel Cancer Research Fund and the Król Charitable Foundation. PH is an EMBO Long-Term Postdoctoral Fellow and ZP a Braun Lecturer.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- EGFR
- Groucho/TLE
- Notch
- Signal transduction
- Transcriptional regulation
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