Crystal structures of pyridinemonocarboxylic acid peroxosolvates

A. G. Medvedev; A. A. Mikhailov; P. V. Prikhodchenko; T. A. Tripol’skaya; O. Lev; A. V. Churakov

doi:10.1007/s11172-013-0269-9

Crystal structures of pyridinemonocarboxylic acid peroxosolvates

A. G. Medvedev, A. A. Mikhailov, P. V. Prikhodchenko, T. A. Tripol’skaya, O. Lev, A. V. Churakov^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The crystal structures of new peroxosolvates of the following pyridinemonocarboxylic acids were studied: picolinic 2-C ₅ H ₄ NCOOH•H ₂ O ₂ (1), nicotinic 3-C ₅ H ₄ NCOOH•H ₂ O ₂ (2), and isonicotinic 4-C5H4NCOOH•2H2O2 (3). In these compounds, the acids exist exclusively as zwitterions, as opposed to non-solvated crystals. In compounds 1-3, the hydrogen peroxide molecules form two donor hydrogen bonds and, in some cases, one additional acceptor hydro- gen bond. Peroxosolvate 2 can be considered as a novel drug formulation of vitamin B ₃ .

Original language	English
Pages (from-to)	1871-1876
Number of pages	6
Journal	Russian Chemical Bulletin
Volume	62
Issue number	8
DOIs	https://doi.org/10.1007/s11172-013-0269-9
State	Published - Aug 2013

Bibliographical note

Funding Information:
This study was financially supported by the Russian Foundation for Basic Research (Project Nos 11 03 92478, 11 03 00551 a, and 11 03 92478 MNTI_a), the Council on Grants at the President of the Russian Federation (Pro gram for State Support of Leading Scientific Schools of the Russian Federation, Grant NSh 1670.2012.3), the Ministry of Education and Science of the Russian Federa tion (Government Contract 8437), and the Ministry of Science and Technology of Israel.

Keywords

Crystal packing
Drug formulation
Hydrogen bonding
Hydrogen peroxide
Peroxosolvates
Pyridinemonocarboxylic acids
X-ray dif- fraction

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title = "Crystal structures of pyridinemonocarboxylic acid peroxosolvates",

abstract = " The crystal structures of new peroxosolvates of the following pyridinemonocarboxylic acids were studied: picolinic 2-C 5 H 4 NCOOH•H 2 O 2 (1), nicotinic 3-C 5 H 4 NCOOH•H 2 O 2 (2), and isonicotinic 4-C5H4NCOOH•2H2O2 (3). In these compounds, the acids exist exclusively as zwitterions, as opposed to non-solvated crystals. In compounds 1-3, the hydrogen peroxide molecules form two donor hydrogen bonds and, in some cases, one additional acceptor hydro- gen bond. Peroxosolvate 2 can be considered as a novel drug formulation of vitamin B 3 .",

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note = "Funding Information: This study was financially supported by the Russian Foundation for Basic Research (Project Nos 11 03 92478, 11 03 00551 a, and 11 03 92478 MNTI_a), the Council on Grants at the President of the Russian Federation (Pro gram for State Support of Leading Scientific Schools of the Russian Federation, Grant NSh 1670.2012.3), the Ministry of Education and Science of the Russian Federa tion (Government Contract 8437), and the Ministry of Science and Technology of Israel.",

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doi = "10.1007/s11172-013-0269-9",

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AU - Mikhailov, A. A.

AU - Prikhodchenko, P. V.

AU - Tripol’skaya, T. A.

AU - Lev, O.

AU - Churakov, A. V.

N1 - Funding Information: This study was financially supported by the Russian Foundation for Basic Research (Project Nos 11 03 92478, 11 03 00551 a, and 11 03 92478 MNTI_a), the Council on Grants at the President of the Russian Federation (Pro gram for State Support of Leading Scientific Schools of the Russian Federation, Grant NSh 1670.2012.3), the Ministry of Education and Science of the Russian Federa tion (Government Contract 8437), and the Ministry of Science and Technology of Israel.

PY - 2013/8

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N2 - The crystal structures of new peroxosolvates of the following pyridinemonocarboxylic acids were studied: picolinic 2-C 5 H 4 NCOOH•H 2 O 2 (1), nicotinic 3-C 5 H 4 NCOOH•H 2 O 2 (2), and isonicotinic 4-C5H4NCOOH•2H2O2 (3). In these compounds, the acids exist exclusively as zwitterions, as opposed to non-solvated crystals. In compounds 1-3, the hydrogen peroxide molecules form two donor hydrogen bonds and, in some cases, one additional acceptor hydro- gen bond. Peroxosolvate 2 can be considered as a novel drug formulation of vitamin B 3 .

AB - The crystal structures of new peroxosolvates of the following pyridinemonocarboxylic acids were studied: picolinic 2-C 5 H 4 NCOOH•H 2 O 2 (1), nicotinic 3-C 5 H 4 NCOOH•H 2 O 2 (2), and isonicotinic 4-C5H4NCOOH•2H2O2 (3). In these compounds, the acids exist exclusively as zwitterions, as opposed to non-solvated crystals. In compounds 1-3, the hydrogen peroxide molecules form two donor hydrogen bonds and, in some cases, one additional acceptor hydro- gen bond. Peroxosolvate 2 can be considered as a novel drug formulation of vitamin B 3 .

KW - Crystal packing

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KW - Hydrogen bonding

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KW - Peroxosolvates

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KW - X-ray dif- fraction

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Crystal structures of pyridinemonocarboxylic acid peroxosolvates

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