Crystal structures of pyridinemonocarboxylic acid peroxosolvates

A. G. Medvedev, A. A. Mikhailov, P. V. Prikhodchenko, T. A. Tripol’skaya, O. Lev, A. V. Churakov*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The crystal structures of new peroxosolvates of the following pyridinemonocarboxylic acids were studied: picolinic 2-C 5 H 4 NCOOH•H 2 O 2 (1), nicotinic 3-C 5 H 4 NCOOH•H 2 O 2 (2), and isonicotinic 4-C5H4NCOOH•2H2O2 (3). In these compounds, the acids exist exclusively as zwitterions, as opposed to non-solvated crystals. In compounds 1-3, the hydrogen peroxide molecules form two donor hydrogen bonds and, in some cases, one additional acceptor hydro- gen bond. Peroxosolvate 2 can be considered as a novel drug formulation of vitamin B 3 .

Original languageAmerican English
Pages (from-to)1871-1876
Number of pages6
JournalRussian Chemical Bulletin
Issue number8
StatePublished - Aug 2013

Bibliographical note

Funding Information:
This study was financially supported by the Russian Foundation for Basic Research (Project Nos 11 03 92478, 11 03 00551 a, and 11 03 92478 MNTI_a), the Council on Grants at the President of the Russian Federation (Pro gram for State Support of Leading Scientific Schools of the Russian Federation, Grant NSh 1670.2012.3), the Ministry of Education and Science of the Russian Federa tion (Government Contract 8437), and the Ministry of Science and Technology of Israel.


  • Crystal packing
  • Drug formulation
  • Hydrogen bonding
  • Hydrogen peroxide
  • Peroxosolvates
  • Pyridinemonocarboxylic acids
  • X-ray dif- fraction


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