Crystallization of cyclosporin A in lyotropic reverse hexagonal liquid crystals

Dima Libster, Abraham Aserin, Idit Amar-Yuli, Tehila Mishraki, Yael Domovich-Eisenberg, Oded Livnah, Nissim Garti*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

In this communication we demonstrate for the first time that lyotropic reverse hexagonal mesophase can serve as a crystallization medium for a hydrophobic peptide, resulting in high quality single crystals suitable for crystallographic analysis. The obtained crystals of cyclosporin A enabled excellent X-ray data collection, diffracting to a resolution limit of 1.0 . Current findings open a new perspective in the field of crystallization of biological macromolecules in lyotropic mesophases.

Original languageAmerican English
Pages (from-to)2034-2036
Number of pages3
JournalCrystEngComm
Volume12
Issue number7
DOIs
StatePublished - Jul 2010

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