Crystals of 70S ribosomes from thermophilic bacteria are suitable for X-ray amalysis at low resolution

Z. Berkovitch-Yellin*, H. A.S. Hansen, W. S. Bennett, R. Sharon, K. von Boehlen, N. Volkmann, J. Piefke, A. Yonath, H. G. Wittmann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Single crystals of 70S ribosomes from Thermus thermophilus and from the wild-type and a mutant of Bacillus stearothermophilus have been obtained. Using synchroton X-ray beam, these crystals diffract to 19 Å and 35 Å, respectively, and can be irradiated at temperatures of 110-120 K for days without noticeable decay. Diffraction data sets to 22 Å and to 33 Å with reasonable R scale were collected from the crystals of 70S from T. thermophilus. The cell dimensions (a = b = 524 Å, c = 315 Å), the symmetry (P41212 or P43212) and the density (1.063 g/cm3) of these crystals indicate that there is one 70S ribosome per asymmetric unit.

Original languageEnglish
Pages (from-to)208-213
Number of pages6
JournalJournal of Crystal Growth
Volume110
Issue number1-2
DOIs
StatePublished - 1 Mar 1991
Externally publishedYes

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