Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families

Thibaut S. Matis; Nadia Zayed; Bouchra Labraki; Manon de Ladurantaye; Théophane A. Matis; José Camacho Valenzuela; Nancy Hamel; Adrienne Atayan; Barbara Rivera; Yuval Tabach; Patricia N. Tonin; Alexandre Orthwein; Anne Marie Mes-Masson; Zaki El Haffaf; William D. Foulkes; Paz Polak

doi:10.1038/s41523-021-00315-8

Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families

Thibaut S. Matis, Nadia Zayed, Bouchra Labraki, Manon de Ladurantaye, Théophane A. Matis, José Camacho Valenzuela, Nancy Hamel, Adrienne Atayan, Barbara Rivera, Yuval Tabach, Patricia N. Tonin, Alexandre Orthwein, Anne Marie Mes-Masson, Zaki El Haffaf, William D. Foulkes^*, Paz Polak

^*Corresponding author for this work

Department of Developmental Biology and Cancer Research

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC) families. We investigated HR deficiency (HRD)-associated mutational signatures and second hits in tumor DNA from familial BC cases. No candidates genes were associated with HRD in 38 probands previously tested negative with gene panels. We conclude it is unlikely that unknown HRD-associated genes explain a large fraction of unsolved familial BC.

Original language	American English
Article number	109
Journal	npj Breast Cancer
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41523-021-00315-8
State	Published - Dec 2021

Bibliographical note

Funding Information:
This study, including the acquisition of archived samples, was funded by a Quebec Breast Cancer Foundation (QBCF) grant to W.D.F. and P.T. Tumor banking was supported in part by the Banque de tissus et de données of the Réseau de recherche sur le cancer of the Fonds de recherche du Québec Santé (FRQS) affiliated with the Canadian Tumor Repository Network (CTRNet). Y.T. is supported by Israel Science Foundation grant. A.O. is supported by CCSRI Innovation Grant and Canada Research Chair Tier 2 in Genome Stability and Hematological Malignancies. P.P. is supported by the Jimmy V foundation scholar award.

Publisher Copyright:
© 2021, The Author(s).

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10.1038/s41523-021-00315-8

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Matis, T. S., Zayed, N., Labraki, B., de Ladurantaye, M., Matis, T. A., Camacho Valenzuela, J., Hamel, N., Atayan, A., Rivera, B., Tabach, Y., Tonin, P. N., Orthwein, A., Mes-Masson, A. M., El Haffaf, Z., Foulkes, W. D., & Polak, P. (2021). Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families. npj Breast Cancer, 7(1), Article 109. https://doi.org/10.1038/s41523-021-00315-8

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title = "Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families",

abstract = "It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC) families. We investigated HR deficiency (HRD)-associated mutational signatures and second hits in tumor DNA from familial BC cases. No candidates genes were associated with HRD in 38 probands previously tested negative with gene panels. We conclude it is unlikely that unknown HRD-associated genes explain a large fraction of unsolved familial BC.",

author = "Matis, {Thibaut S.} and Nadia Zayed and Bouchra Labraki and {de Ladurantaye}, Manon and Matis, {Th{\'e}ophane A.} and {Camacho Valenzuela}, Jos{\'e} and Nancy Hamel and Adrienne Atayan and Barbara Rivera and Yuval Tabach and Tonin, {Patricia N.} and Alexandre Orthwein and Mes-Masson, {Anne Marie} and {El Haffaf}, Zaki and Foulkes, {William D.} and Paz Polak",

note = "Funding Information: This study, including the acquisition of archived samples, was funded by a Quebec Breast Cancer Foundation (QBCF) grant to W.D.F. and P.T. Tumor banking was supported in part by the Banque de tissus et de donn{\'e}es of the R{\'e}seau de recherche sur le cancer of the Fonds de recherche du Qu{\'e}bec Sant{\'e} (FRQS) affiliated with the Canadian Tumor Repository Network (CTRNet). Y.T. is supported by Israel Science Foundation grant. A.O. is supported by CCSRI Innovation Grant and Canada Research Chair Tier 2 in Genome Stability and Hematological Malignancies. P.P. is supported by the Jimmy V foundation scholar award. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1038/s41523-021-00315-8",

language = "American English",

volume = "7",

journal = "npj Breast Cancer",

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Matis, TS, Zayed, N, Labraki, B, de Ladurantaye, M, Matis, TA, Camacho Valenzuela, J, Hamel, N, Atayan, A, Rivera, B, Tabach, Y, Tonin, PN, Orthwein, A, Mes-Masson, AM, El Haffaf, Z, Foulkes, WD & Polak, P 2021, 'Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families', npj Breast Cancer, vol. 7, no. 1, 109. https://doi.org/10.1038/s41523-021-00315-8

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AU - Zayed, Nadia

AU - Labraki, Bouchra

AU - de Ladurantaye, Manon

AU - Matis, Théophane A.

AU - Camacho Valenzuela, José

AU - Hamel, Nancy

AU - Atayan, Adrienne

AU - Rivera, Barbara

AU - Tabach, Yuval

AU - Tonin, Patricia N.

AU - Orthwein, Alexandre

AU - Mes-Masson, Anne Marie

AU - El Haffaf, Zaki

AU - Foulkes, William D.

AU - Polak, Paz

N1 - Funding Information: This study, including the acquisition of archived samples, was funded by a Quebec Breast Cancer Foundation (QBCF) grant to W.D.F. and P.T. Tumor banking was supported in part by the Banque de tissus et de données of the Réseau de recherche sur le cancer of the Fonds de recherche du Québec Santé (FRQS) affiliated with the Canadian Tumor Repository Network (CTRNet). Y.T. is supported by Israel Science Foundation grant. A.O. is supported by CCSRI Innovation Grant and Canada Research Chair Tier 2 in Genome Stability and Hematological Malignancies. P.P. is supported by the Jimmy V foundation scholar award. Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC) families. We investigated HR deficiency (HRD)-associated mutational signatures and second hits in tumor DNA from familial BC cases. No candidates genes were associated with HRD in 38 probands previously tested negative with gene panels. We conclude it is unlikely that unknown HRD-associated genes explain a large fraction of unsolved familial BC.

AB - It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC) families. We investigated HR deficiency (HRD)-associated mutational signatures and second hits in tumor DNA from familial BC cases. No candidates genes were associated with HRD in 38 probands previously tested negative with gene panels. We conclude it is unlikely that unknown HRD-associated genes explain a large fraction of unsolved familial BC.

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ER -

Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families

Abstract

Bibliographical note

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