Cusp tear in bicuspid aortic valve possibly caused by phentermine

Chaim Yosefy*, Michael Berman, Ronen Beeri

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A 28 year old woman underwent echocardiography following an incidental finding of a diastolic murmur. She has been taking phentermine for weight reduction for 8 months. Trans-esophageal echocardiography revealed a tear of the posterior cusp of the aortic valve causing severe regurgitation. Phentermine is known to cause valvular disease with prolonged use, but aortic valve rupture was not previously reported as a complication of phentermine valvulopathy.

Original languageAmerican English
Pages (from-to)262-263
Number of pages2
JournalInternational Journal of Cardiology
Issue number2
StatePublished - 13 Jan 2006
Externally publishedYes


  • Bicuspid aortic valve
  • Cusp tear
  • Phentermine


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