Cyclic AMP second messenger signal generation in EBV-transformed lymphoblastoid cells from schizophrenic patients

R. P. Ebstein*, E. R. Bennett, J. Hadjez, H. Silver, S. Yedgar, B. Lerer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Several aspects of cyclic AMP second messenger signal generation were examined in EBV-transformed cell lines from 12 schizophrenic patients and 12 age-and sex-matched controls. No evidence was obtained suggesting a heritable abnormality in cyclic AMP synthesis in schizophrenia. Basal, forskolin, A1/NaF- and GppNHp-stimulated cyclic AMP synthesis in membranes from transformed cell lines was identical for schizophrenic and control subjects. In addition, no significant differences were observed for basal, forskolin-, isoproterenol- and prostaglandin E1-stimulated cyclic AMP accumulation in intact cell lines derived from ten of the schizophrenic patients compared with cell lines derived from ten of the control subjects.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalJournal of Psychiatric Research
Volume24
Issue number2
DOIs
StatePublished - 1990

Fingerprint

Dive into the research topics of 'Cyclic AMP second messenger signal generation in EBV-transformed lymphoblastoid cells from schizophrenic patients'. Together they form a unique fingerprint.

Cite this