TY - JOUR
T1 - Cyclic AMP second messenger signal generation in EBV-transformed lymphoblastoid cells from schizophrenic patients
AU - Ebstein, R. P.
AU - Bennett, E. R.
AU - Hadjez, J.
AU - Silver, H.
AU - Yedgar, S.
AU - Lerer, B.
PY - 1990
Y1 - 1990
N2 - Several aspects of cyclic AMP second messenger signal generation were examined in EBV-transformed cell lines from 12 schizophrenic patients and 12 age-and sex-matched controls. No evidence was obtained suggesting a heritable abnormality in cyclic AMP synthesis in schizophrenia. Basal, forskolin, A1/NaF- and GppNHp-stimulated cyclic AMP synthesis in membranes from transformed cell lines was identical for schizophrenic and control subjects. In addition, no significant differences were observed for basal, forskolin-, isoproterenol- and prostaglandin E1-stimulated cyclic AMP accumulation in intact cell lines derived from ten of the schizophrenic patients compared with cell lines derived from ten of the control subjects.
AB - Several aspects of cyclic AMP second messenger signal generation were examined in EBV-transformed cell lines from 12 schizophrenic patients and 12 age-and sex-matched controls. No evidence was obtained suggesting a heritable abnormality in cyclic AMP synthesis in schizophrenia. Basal, forskolin, A1/NaF- and GppNHp-stimulated cyclic AMP synthesis in membranes from transformed cell lines was identical for schizophrenic and control subjects. In addition, no significant differences were observed for basal, forskolin-, isoproterenol- and prostaglandin E1-stimulated cyclic AMP accumulation in intact cell lines derived from ten of the schizophrenic patients compared with cell lines derived from ten of the control subjects.
UR - http://www.scopus.com/inward/record.url?scp=0024990230&partnerID=8YFLogxK
U2 - 10.1016/0022-3956(90)90052-R
DO - 10.1016/0022-3956(90)90052-R
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C2 - 2170638
AN - SCOPUS:0024990230
SN - 0022-3956
VL - 24
SP - 121
EP - 127
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 2
ER -