Cyclic AMP second messenger signal generation in EBV-transformed lymphoblastoid cells from schizophrenic patients

R. P. Ebstein; E. R. Bennett; J. Hadjez; H. Silver; S. Yedgar; B. Lerer

doi:10.1016/0022-3956(90)90052-R

Cyclic AMP second messenger signal generation in EBV-transformed lymphoblastoid cells from schizophrenic patients

R. P. Ebstein^*
, E. R. Bennett
, J. Hadjez
, H. Silver
, S. Yedgar
, B. Lerer

^*Corresponding author for this work

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Several aspects of cyclic AMP second messenger signal generation were examined in EBV-transformed cell lines from 12 schizophrenic patients and 12 age-and sex-matched controls. No evidence was obtained suggesting a heritable abnormality in cyclic AMP synthesis in schizophrenia. Basal, forskolin, A1/NaF- and GppNHp-stimulated cyclic AMP synthesis in membranes from transformed cell lines was identical for schizophrenic and control subjects. In addition, no significant differences were observed for basal, forskolin-, isoproterenol- and prostaglandin E₁-stimulated cyclic AMP accumulation in intact cell lines derived from ten of the schizophrenic patients compared with cell lines derived from ten of the control subjects.

Original language	English
Pages (from-to)	121-127
Number of pages	7
Journal	Journal of Psychiatric Research
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/0022-3956(90)90052-R
State	Published - 1990

Access to Document

10.1016/0022-3956(90)90052-R

Cite this

@article{1ac12282e9354d11beaaa0e8b3870163,

title = "Cyclic AMP second messenger signal generation in EBV-transformed lymphoblastoid cells from schizophrenic patients",

abstract = "Several aspects of cyclic AMP second messenger signal generation were examined in EBV-transformed cell lines from 12 schizophrenic patients and 12 age-and sex-matched controls. No evidence was obtained suggesting a heritable abnormality in cyclic AMP synthesis in schizophrenia. Basal, forskolin, A1/NaF- and GppNHp-stimulated cyclic AMP synthesis in membranes from transformed cell lines was identical for schizophrenic and control subjects. In addition, no significant differences were observed for basal, forskolin-, isoproterenol- and prostaglandin E1-stimulated cyclic AMP accumulation in intact cell lines derived from ten of the schizophrenic patients compared with cell lines derived from ten of the control subjects.",

author = "Ebstein, \{R. P.\} and Bennett, \{E. R.\} and J. Hadjez and H. Silver and S. Yedgar and B. Lerer",

year = "1990",

doi = "10.1016/0022-3956(90)90052-R",

language = "אנגלית",

volume = "24",

pages = "121--127",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Elsevier Ltd.",

number = "2",

}

TY - JOUR

T1 - Cyclic AMP second messenger signal generation in EBV-transformed lymphoblastoid cells from schizophrenic patients

AU - Ebstein, R. P.

AU - Bennett, E. R.

AU - Hadjez, J.

AU - Silver, H.

AU - Yedgar, S.

AU - Lerer, B.

PY - 1990

Y1 - 1990

N2 - Several aspects of cyclic AMP second messenger signal generation were examined in EBV-transformed cell lines from 12 schizophrenic patients and 12 age-and sex-matched controls. No evidence was obtained suggesting a heritable abnormality in cyclic AMP synthesis in schizophrenia. Basal, forskolin, A1/NaF- and GppNHp-stimulated cyclic AMP synthesis in membranes from transformed cell lines was identical for schizophrenic and control subjects. In addition, no significant differences were observed for basal, forskolin-, isoproterenol- and prostaglandin E1-stimulated cyclic AMP accumulation in intact cell lines derived from ten of the schizophrenic patients compared with cell lines derived from ten of the control subjects.

AB - Several aspects of cyclic AMP second messenger signal generation were examined in EBV-transformed cell lines from 12 schizophrenic patients and 12 age-and sex-matched controls. No evidence was obtained suggesting a heritable abnormality in cyclic AMP synthesis in schizophrenia. Basal, forskolin, A1/NaF- and GppNHp-stimulated cyclic AMP synthesis in membranes from transformed cell lines was identical for schizophrenic and control subjects. In addition, no significant differences were observed for basal, forskolin-, isoproterenol- and prostaglandin E1-stimulated cyclic AMP accumulation in intact cell lines derived from ten of the schizophrenic patients compared with cell lines derived from ten of the control subjects.

UR - https://www.scopus.com/pages/publications/0024990230

U2 - 10.1016/0022-3956(90)90052-R

DO - 10.1016/0022-3956(90)90052-R

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 2170638

AN - SCOPUS:0024990230

SN - 0022-3956

VL - 24

SP - 121

EP - 127

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

IS - 2

ER -

Cyclic AMP second messenger signal generation in EBV-transformed lymphoblastoid cells from schizophrenic patients

Abstract

Access to Document

Other files and links

Fingerprint

Cite this