TY - JOUR
T1 - Cyclic dissociation into stable subunits and re-formation of ribosomes during bacterial growth
AU - Kaempfer, Raymond O.R.
AU - Meselson, Matthew
AU - Raskas, Heschel J.
PY - 1968/1/28
Y1 - 1968/1/28
N2 - Studies of the distribution of isotopic labels among ribosomes and ribosomal subunits following transfer of a growing bacterial culture from a heavy- to a light-isotopes medium show that: 1. (1) During growth ribosomes frequently undergo subunit exchange, presumably by dissociation into their 30 s and 50 s subunits and re-formation from a pool of free subunits. 2. (2) Bibosomal subunits are stable: they remain intact during growth and are continuously, recycled through ribosomes. On the basis of these results, it is suggested that ribosomes must dissociate into their subunits between successive rounds of translation.
AB - Studies of the distribution of isotopic labels among ribosomes and ribosomal subunits following transfer of a growing bacterial culture from a heavy- to a light-isotopes medium show that: 1. (1) During growth ribosomes frequently undergo subunit exchange, presumably by dissociation into their 30 s and 50 s subunits and re-formation from a pool of free subunits. 2. (2) Bibosomal subunits are stable: they remain intact during growth and are continuously, recycled through ribosomes. On the basis of these results, it is suggested that ribosomes must dissociate into their subunits between successive rounds of translation.
UR - http://www.scopus.com/inward/record.url?scp=0014432524&partnerID=8YFLogxK
U2 - 10.1016/0022-2836(68)90444-0
DO - 10.1016/0022-2836(68)90444-0
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C2 - 4865485
AN - SCOPUS:0014432524
SN - 0022-2836
VL - 31
SP - 277
EP - 289
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
IS - 2
ER -