TY - JOUR
T1 - Cyclobutane-containing alkaloids
T2 - origin, synthesis, and biological activities
AU - Sergeiko, Anastasia
AU - Poroikov, Vladimir V
AU - Hanus, Lumir O
AU - Dembitsky, Valery M
PY - 2008/4/15
Y1 - 2008/4/15
N2 - Present review describes research on novel natural cyclobutane-containing alkaloids isolated from terrestrial and marine species. More than 60 biological active compounds have been confirmed to have antimicrobial, antibacterial, antitumor, and other activities. The structures, synthesis, origins, and biological activities of a selection of cyclobutane-containing alkaloids are reviewed. With the computer program PASS some additional biological activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of cyclobutane-containing alkaloids as an important source of leads for drug discovery.
AB - Present review describes research on novel natural cyclobutane-containing alkaloids isolated from terrestrial and marine species. More than 60 biological active compounds have been confirmed to have antimicrobial, antibacterial, antitumor, and other activities. The structures, synthesis, origins, and biological activities of a selection of cyclobutane-containing alkaloids are reviewed. With the computer program PASS some additional biological activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of cyclobutane-containing alkaloids as an important source of leads for drug discovery.
U2 - 10.2174/1874104500802010026
DO - 10.2174/1874104500802010026
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C2 - 19696873
SN - 1874-1045
VL - 2
SP - 26
EP - 37
JO - Open Medicinal Chemistry Journal
JF - Open Medicinal Chemistry Journal
ER -