Cyclopentane FIT-PNAs: Bright RNA sensors

Odelia Tepper*, Hongchao Zheng, Daniel H. Appella, Eylon Yavin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).

Original languageAmerican English
Pages (from-to)540-543
Number of pages4
JournalChemical Communications
Volume57
Issue number4
DOIs
StatePublished - 14 Jan 2021

Bibliographical note

Funding Information:
This research was supported by THE ISRAEL SCIENCE FOUNDATION (grant no. 476/17). EY acknowledges the David R. Bloom Center for Pharmacy and the Alex Grass Center for Drug Design and Synthesis of Novel Therapeutics for financial support. The authors are grateful to Prof. Gonen Ashkenasy for help with Tm measurements.

Publisher Copyright:
© 2021 The Royal Society of Chemistry.

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