Cyclopentane FIT-PNAs: Bright RNA sensors

Odelia Tepper; Hongchao Zheng; Daniel H. Appella; Eylon Yavin

doi:10.1039/d0cc07400d

Cyclopentane FIT-PNAs: Bright RNA sensors

Odelia Tepper^*, Hongchao Zheng, Daniel H. Appella, Eylon Yavin

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).

Original language	English
Pages (from-to)	540-543
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	4
DOIs	https://doi.org/10.1039/d0cc07400d
State	Published - 14 Jan 2021

Bibliographical note

Funding Information:
This research was supported by THE ISRAEL SCIENCE FOUNDATION (grant no. 476/17). EY acknowledges the David R. Bloom Center for Pharmacy and the Alex Grass Center for Drug Design and Synthesis of Novel Therapeutics for financial support. The authors are grateful to Prof. Gonen Ashkenasy for help with Tm measurements.

Publisher Copyright:
© 2021 The Royal Society of Chemistry.

Access to Document

10.1039/d0cc07400d

Cite this

@article{c9751cb049964bc5865183102719d256,

title = "Cyclopentane FIT-PNAs: Bright RNA sensors",

abstract = "Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).",

author = "Odelia Tepper and Hongchao Zheng and Appella, {Daniel H.} and Eylon Yavin",

note = "Publisher Copyright: {\textcopyright} 2021 The Royal Society of Chemistry.",

year = "2021",

month = jan,

day = "14",

doi = "10.1039/d0cc07400d",

language = "אנגלית",

volume = "57",

pages = "540--543",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "4",

}

TY - JOUR

T1 - Cyclopentane FIT-PNAs

T2 - Bright RNA sensors

AU - Tepper, Odelia

AU - Zheng, Hongchao

AU - Appella, Daniel H.

AU - Yavin, Eylon

PY - 2021/1/14

Y1 - 2021/1/14

N2 - Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).

AB - Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).

UR - http://www.scopus.com/inward/record.url?scp=85099559632&partnerID=8YFLogxK

U2 - 10.1039/d0cc07400d

DO - 10.1039/d0cc07400d

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 33336664

AN - SCOPUS:85099559632

SN - 1359-7345

VL - 57

SP - 540

EP - 543

JO - Chemical Communications

JF - Chemical Communications

IS - 4

ER -

Cyclopentane FIT-PNAs: Bright RNA sensors

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this