TY - JOUR
T1 - Cyclosporin Increases the CNS Sensitivity to the Hypnotic Effect of Phenobarbitone but not Ethanol in Rats
AU - HOFFMAN, AMNON
AU - HABIB, GUSTAV
AU - GILHAR, DALIA
AU - ZOHAR, HILA
PY - 1994/9
Y1 - 1994/9
N2 - Abstract— The purpose of this investigation was to determine whether repetitive administration of cyclosporin affects the pharmacodynamics of phenobarbitone‐ and ethanol‐induced anaesthesia. Sabra male rats received either cyclosporin (50 mg kg−1 day−1, i.m.) for four days, or the same volume of the vehicle. Two hours after the last cyclosporin dose, phenobarbitone or ethanol solutions were infused intravenously at a constant rate until the onset of anaesthesia. Repetitive treatment with cyclosporin increased the CNS sensitivity to the hypnotic action of phenobarbitone. This was evidenced by the lower CSF phenobarbitone concentration, at the onset of the hypnotic effect, in the cyclosporin‐treated group vs control values (115 ± 4 vs 93 ± 7 mg L−1, P = 0·01). However, the same pretreatment had no apparent effect on the pharmacodynamics of ethanol‐induced sleep. It is suggested that anaesthesiologists must be alert to the possible increase in brain sensitivity when placing cyclosporin patients under anaesthesia with barbiturates. 1994 Royal Pharmaceutical Society of Great Britain
AB - Abstract— The purpose of this investigation was to determine whether repetitive administration of cyclosporin affects the pharmacodynamics of phenobarbitone‐ and ethanol‐induced anaesthesia. Sabra male rats received either cyclosporin (50 mg kg−1 day−1, i.m.) for four days, or the same volume of the vehicle. Two hours after the last cyclosporin dose, phenobarbitone or ethanol solutions were infused intravenously at a constant rate until the onset of anaesthesia. Repetitive treatment with cyclosporin increased the CNS sensitivity to the hypnotic action of phenobarbitone. This was evidenced by the lower CSF phenobarbitone concentration, at the onset of the hypnotic effect, in the cyclosporin‐treated group vs control values (115 ± 4 vs 93 ± 7 mg L−1, P = 0·01). However, the same pretreatment had no apparent effect on the pharmacodynamics of ethanol‐induced sleep. It is suggested that anaesthesiologists must be alert to the possible increase in brain sensitivity when placing cyclosporin patients under anaesthesia with barbiturates. 1994 Royal Pharmaceutical Society of Great Britain
UR - http://www.scopus.com/inward/record.url?scp=0027939942&partnerID=8YFLogxK
U2 - 10.1111/j.2042-7158.1994.tb03898.x
DO - 10.1111/j.2042-7158.1994.tb03898.x
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C2 - 7837047
AN - SCOPUS:0027939942
SN - 0022-3573
VL - 46
SP - 760
EP - 764
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 9
ER -