TY - JOUR
T1 - Cyprinid herpes virus-3 (CyHV-3) bears genes of genetically distant large DNA viruses
AU - Ilouze, Maya
AU - Dishon, Arnon
AU - Kahan, Tamar
AU - Kotler, Moshe
PY - 2006/8/7
Y1 - 2006/8/7
N2 - A large DNA virus, designated koi herpes virus (KHV), carp interstitial nephritis gill necrosis virus (CNGV) and Cyprinid herpes virus-3 (CyHV-3), causes massive mortality of carp. Morphologically, the virus resembles herpes viruses, but it contains a genome of ca 295 kbp, larger than that of any Herpesviridae member. Interestingly, three CyHV-3 genes, thymidylate monophosphate kinase (TmpK), ribonucleotide reductase and thymidine kinase, which are involved in deoxynucleotide tri-phosphate synthesis, resemble those of pox viruses. In addition to the TmpK gene, which is nonexistent in the genome of herpes viruses, CyHV-3 contains a B22R-like gene, exclusively expressed by pox viruses. These results raise questions on the phylogenic origin of CyHV-3.
AB - A large DNA virus, designated koi herpes virus (KHV), carp interstitial nephritis gill necrosis virus (CNGV) and Cyprinid herpes virus-3 (CyHV-3), causes massive mortality of carp. Morphologically, the virus resembles herpes viruses, but it contains a genome of ca 295 kbp, larger than that of any Herpesviridae member. Interestingly, three CyHV-3 genes, thymidylate monophosphate kinase (TmpK), ribonucleotide reductase and thymidine kinase, which are involved in deoxynucleotide tri-phosphate synthesis, resemble those of pox viruses. In addition to the TmpK gene, which is nonexistent in the genome of herpes viruses, CyHV-3 contains a B22R-like gene, exclusively expressed by pox viruses. These results raise questions on the phylogenic origin of CyHV-3.
KW - CNGV
KW - CyHV-3
KW - Genetic divergence
KW - KHV
KW - Pox-like genes
UR - http://www.scopus.com/inward/record.url?scp=33746346174&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2006.07.013
DO - 10.1016/j.febslet.2006.07.013
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C2 - 16860321
AN - SCOPUS:33746346174
SN - 0014-5793
VL - 580
SP - 4473
EP - 4478
JO - FEBS Letters
JF - FEBS Letters
IS - 18
ER -