Abstract
A large DNA virus, designated koi herpes virus (KHV), carp interstitial nephritis gill necrosis virus (CNGV) and Cyprinid herpes virus-3 (CyHV-3), causes massive mortality of carp. Morphologically, the virus resembles herpes viruses, but it contains a genome of ca 295 kbp, larger than that of any Herpesviridae member. Interestingly, three CyHV-3 genes, thymidylate monophosphate kinase (TmpK), ribonucleotide reductase and thymidine kinase, which are involved in deoxynucleotide tri-phosphate synthesis, resemble those of pox viruses. In addition to the TmpK gene, which is nonexistent in the genome of herpes viruses, CyHV-3 contains a B22R-like gene, exclusively expressed by pox viruses. These results raise questions on the phylogenic origin of CyHV-3.
| Original language | English |
|---|---|
| Pages (from-to) | 4473-4478 |
| Number of pages | 6 |
| Journal | FEBS Letters |
| Volume | 580 |
| Issue number | 18 |
| DOIs | |
| State | Published - 7 Aug 2006 |
Keywords
- CNGV
- CyHV-3
- Genetic divergence
- KHV
- Pox-like genes
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