Cysteamine suppresses kindled seizures in pentylenetetrazol-kindled rats

Georges Assouline; Edy Barkaie; Michael J. Gutnick

doi:10.1016/0014-2999(84)90073-6

Cysteamine suppresses kindled seizures in pentylenetetrazol-kindled rats

Georges Assouline, Edy Barkaie, Michael J. Gutnick^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) (30 mg/kg) every 48 h. Once kindled, animals received a single injection of cysteamine (200 mg/kg) and subsequent responses to PTZ were observed. Cysteamine, an agent which depletes brain somatostatin and suppresses kindled seizures in amygdaloid-kindled rats, markedly suppressed the severity of PTZ-induced seizures in PTZ-kindled rats as well. However, it did not alter the convulsive response of non-kindled rats to a submaximal convulsive dose (50 mg/kg) of PTZ. The results support a role for somatostatin in kindling.

Original language	English
Pages (from-to)	649-652
Number of pages	4
Journal	European Journal of Pharmacology
Volume	106
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(84)90073-6
State	Published - 27 Nov 1984
Externally published	Yes

Keywords

Cysteamine
Kindling
Pentylenetrazol
Seizures
Somatostatin

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10.1016/0014-2999(84)90073-6

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title = "Cysteamine suppresses kindled seizures in pentylenetetrazol-kindled rats",

abstract = "Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) (30 mg/kg) every 48 h. Once kindled, animals received a single injection of cysteamine (200 mg/kg) and subsequent responses to PTZ were observed. Cysteamine, an agent which depletes brain somatostatin and suppresses kindled seizures in amygdaloid-kindled rats, markedly suppressed the severity of PTZ-induced seizures in PTZ-kindled rats as well. However, it did not alter the convulsive response of non-kindled rats to a submaximal convulsive dose (50 mg/kg) of PTZ. The results support a role for somatostatin in kindling.",

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AU - Barkaie, Edy

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Cysteamine suppresses kindled seizures in pentylenetetrazol-kindled rats

Abstract

Keywords

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