Cytidine Triphosphate Synthetase. Covalent Intermediates and Mechanisms of Action

Alexander Levitzki

doi:10.1021/bi00794a008

Cytidine Triphosphate Synthetase. Covalent Intermediates and Mechanisms of Action

Alexander Levitzki^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

The mechanism of CTP-synthetase from Escherichia coli B was elucidated and appears to be composed of the steps given in the adjacent column. Ammonia can replace glutamine as the amino donor. Evidence is presented that externally added ammonia and the nascent ammonia released from the glutamine reaction occupy the same site.

Original language	English
Pages (from-to)	3365-3371
Number of pages	7
Journal	Biochemistry
Volume	10
Issue number	18
DOIs	https://doi.org/10.1021/bi00794a008
State	Published - 1 Aug 1971
Externally published	Yes

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abstract = "The mechanism of CTP-synthetase from Escherichia coli B was elucidated and appears to be composed of the steps given in the adjacent column. Ammonia can replace glutamine as the amino donor. Evidence is presented that externally added ammonia and the nascent ammonia released from the glutamine reaction occupy the same site.",

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Cytidine Triphosphate Synthetase. Covalent Intermediates and Mechanisms of Action

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