Abstract
The COVID-19 outbreak is emerging as a significant public health challenge. Excessive production of proinflammatory cytokines, also known as cytokine storm, is a severe clinical syndrome known to develop as a complication of infectious or inflammatory diseases. Clinical evidence suggests that the occurrence of cytokine storm in severe acute respiratory syndrome secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely associated with the rapid deterioration and high mortality of severe cases. In this review, we aim to summarize the mechanism of SARS-CoV-2 infection and the subsequent immunological events related to excessive cytokine production and inflammatory responses associated with ACE2-AngII signaling. An overview of the diagnosis and an update on current therapeutic regimens and vaccinations is also provided.
Original language | English |
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Pages (from-to) | 459-472 |
Number of pages | 14 |
Journal | International Journal of Biological Sciences |
Volume | 18 |
Issue number | 2 |
DOIs | |
State | Published - 2022 |
Bibliographical note
Publisher Copyright:© The author(s).
Keywords
- COVID-19
- Cytokine storm
- Cytokines
- Diagnosis
- Immune response
- SARS-CoV-2
- Therapy
- Vaccination