Cytoplasmic polyhedrosis viruses in Phlebotomus papatasi inhibit development of Leishmania major.

A. Warburg*, K. Ostrovska

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Cytoplasmic polyhedrosis viruses (CPV's) were observed in wild-caught and laboratory-reared Phlebotomus papatasi. Chronic CPV pathology of the midgut, characterized by structural aberrations in the epithelium and the peritrophic membrane, interfered with blood digestion and rendered the sand flies refractory to Leishmania major infections. Rates of natural and artificial L. major infections were inversely correlated to the incidence of CPV infections. The interaction between viruses and protozoan parasites in an insect host is of basic biological interest and in this case may be of significance in the epidemiology of cutaneous leishmaniasis.

Original languageEnglish
Pages (from-to)578-583
Number of pages6
JournalJournal of Parasitology
Volume73
Issue number3
DOIs
StatePublished - Jun 1987

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