Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

Fatima Gasset-Rosa; Shan Lu; Haiyang Yu; Cong Chen; Ze'ev Melamed; Lin Guo; James Shorter; Sandrine Da Cruz; Don W. Cleveland

doi:10.1016/j.neuron.2019.02.038

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

Fatima Gasset-Rosa
, Shan Lu
, Haiyang Yu
, Cong Chen
, Ze'ev Melamed
, Lin Guo
, James Shorter
, Sandrine Da Cruz^*
, Don W. Cleveland

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

367 Scopus citations

Abstract

TDP-43 aggregation is the major hallmark of multiple neurodegenerative diseases, including ALS and FTD. Gasset-Rosa et al. demonstrate that transient stress induces long-lasting cytoplasmic TDP-43 de-mixing independent of stress granules, driving nuclear import defects, nuclear TDP-43 clearance, and cell death.

Original language	English
Pages (from-to)	339-357.e7
Journal	Neuron
Volume	102
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2019.02.038
State	Published - 17 Apr 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

ALS/FTD
RNA-binding proteins
TDP-43
TDP-43 de-mixing
iPSCs
liquid-liquid phase separation
low complexity domains
motor neurons
neurodegeneration
nucleocytoplasmic transport
stress granules

Access to Document

10.1016/j.neuron.2019.02.038

Cite this

@article{1360d2eb9b9d467490e37807f81872d2,

title = "Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death",

abstract = "TDP-43 aggregation is the major hallmark of multiple neurodegenerative diseases, including ALS and FTD. Gasset-Rosa et al. demonstrate that transient stress induces long-lasting cytoplasmic TDP-43 de-mixing independent of stress granules, driving nuclear import defects, nuclear TDP-43 clearance, and cell death.",

keywords = "ALS/FTD, RNA-binding proteins, TDP-43, TDP-43 de-mixing, iPSCs, liquid-liquid phase separation, low complexity domains, motor neurons, neurodegeneration, nucleocytoplasmic transport, stress granules",

author = "Fatima Gasset-Rosa and Shan Lu and Haiyang Yu and Cong Chen and Ze'ev Melamed and Lin Guo and James Shorter and \{Da Cruz\}, Sandrine and Cleveland, \{Don W.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = apr,

day = "17",

doi = "10.1016/j.neuron.2019.02.038",

language = "אנגלית",

volume = "102",

pages = "339--357.e7",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

AU - Gasset-Rosa, Fatima

AU - Lu, Shan

AU - Yu, Haiyang

AU - Chen, Cong

AU - Melamed, Ze'ev

AU - Guo, Lin

AU - Shorter, James

AU - Da Cruz, Sandrine

AU - Cleveland, Don W.

PY - 2019/4/17

Y1 - 2019/4/17

N2 - TDP-43 aggregation is the major hallmark of multiple neurodegenerative diseases, including ALS and FTD. Gasset-Rosa et al. demonstrate that transient stress induces long-lasting cytoplasmic TDP-43 de-mixing independent of stress granules, driving nuclear import defects, nuclear TDP-43 clearance, and cell death.

AB - TDP-43 aggregation is the major hallmark of multiple neurodegenerative diseases, including ALS and FTD. Gasset-Rosa et al. demonstrate that transient stress induces long-lasting cytoplasmic TDP-43 de-mixing independent of stress granules, driving nuclear import defects, nuclear TDP-43 clearance, and cell death.

KW - ALS/FTD

KW - RNA-binding proteins

KW - TDP-43

KW - TDP-43 de-mixing

KW - iPSCs

KW - liquid-liquid phase separation

KW - low complexity domains

KW - motor neurons

KW - neurodegeneration

KW - nucleocytoplasmic transport

KW - stress granules

UR - https://www.scopus.com/pages/publications/85063668310

U2 - 10.1016/j.neuron.2019.02.038

DO - 10.1016/j.neuron.2019.02.038

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 30853299

AN - SCOPUS:85063668310

SN - 0896-6273

VL - 102

SP - 339-357.e7

JO - Neuron

JF - Neuron

IS - 2

ER -

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this