Cytoskeletal composition of attaching and effacing lesions associated with enteropathogenic Escherichia coli adherence to HeLa cells

B. B. Finlay*, I. Rosenshine, M. S. Donnenberg, J. B. Kaper

*Corresponding author for this work

Research output: Contribution to journalComment/debate

182 Scopus citations

Abstract

The cytoskeletal lesions associated with enteropathogenic Escherichia coli adhering to cultured HeLa epithelial cells were examined by immunofluorescence microscopy. The microfilament-associated proteins actin, α-actinin, talin, and ezrin were localized with adherent enteropathogenic E. coli, whereas tropomyosin, keratin and vimentin (intermediate filaments), tubulin (microtubules), and vinculin were not localized. These cytoskeletal structures differed significantly from those associated with Salmonella typhimurium internalization (invasion).

Original languageEnglish
Pages (from-to)2541-2543
Number of pages3
JournalInfection and Immunity
Volume60
Issue number6
StatePublished - 1992
Externally publishedYes

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