Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands

Hagai Glasner; Edit Y. Tshuva

doi:10.1016/j.inoche.2015.01.019

Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands

Hagai Glasner, Edit Y. Tshuva^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Binuclear O-bridged titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands were obtained from the corresponding ligands and Ti(OiPr)₄ and analyzed by ¹H, ¹³C and diffusion NMR. The comparative hydrolytic stability in 1:9 D₂O/DMSO-d₆ was assessed by ¹H NMR, and the complexes featured t_1/2 values of above 100 h. The cytotoxic activity of the binuclear complexes was measured toward human colon HT-29 cancer cell line by the MTT assay. Although as expected most complexes exhibited mild or no cytotoxic activity, one leading complex demonstrated marked activity with IC₅₀ value of 77 ± 40 μM.

Original language	English
Pages (from-to)	31-33
Number of pages	3
Journal	Inorganic Chemistry Communications
Volume	53
DOIs	https://doi.org/10.1016/j.inoche.2015.01.019
State	Published - May 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

Cisplatin
Cytotoxicity
Metallodrugs
Phenolato ligands
Titanium(IV)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.inoche.2015.01.019

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title = "Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands",

abstract = "Binuclear O-bridged titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands were obtained from the corresponding ligands and Ti(OiPr)4 and analyzed by 1H, 13C and diffusion NMR. The comparative hydrolytic stability in 1:9 D2O/DMSO-d6 was assessed by 1H NMR, and the complexes featured t1/2 values of above 100 h. The cytotoxic activity of the binuclear complexes was measured toward human colon HT-29 cancer cell line by the MTT assay. Although as expected most complexes exhibited mild or no cytotoxic activity, one leading complex demonstrated marked activity with IC50 value of 77 ± 40 μM.",

keywords = "Cisplatin, Cytotoxicity, Metallodrugs, Phenolato ligands, Titanium(IV)",

author = "Hagai Glasner and Tshuva, {Edit Y.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

month = may,

doi = "10.1016/j.inoche.2015.01.019",

language = "אנגלית",

volume = "53",

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journal = "Inorganic Chemistry Communications",

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T1 - Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands

AU - Glasner, Hagai

AU - Tshuva, Edit Y.

PY - 2015/5

Y1 - 2015/5

N2 - Binuclear O-bridged titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands were obtained from the corresponding ligands and Ti(OiPr)4 and analyzed by 1H, 13C and diffusion NMR. The comparative hydrolytic stability in 1:9 D2O/DMSO-d6 was assessed by 1H NMR, and the complexes featured t1/2 values of above 100 h. The cytotoxic activity of the binuclear complexes was measured toward human colon HT-29 cancer cell line by the MTT assay. Although as expected most complexes exhibited mild or no cytotoxic activity, one leading complex demonstrated marked activity with IC50 value of 77 ± 40 μM.

AB - Binuclear O-bridged titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands were obtained from the corresponding ligands and Ti(OiPr)4 and analyzed by 1H, 13C and diffusion NMR. The comparative hydrolytic stability in 1:9 D2O/DMSO-d6 was assessed by 1H NMR, and the complexes featured t1/2 values of above 100 h. The cytotoxic activity of the binuclear complexes was measured toward human colon HT-29 cancer cell line by the MTT assay. Although as expected most complexes exhibited mild or no cytotoxic activity, one leading complex demonstrated marked activity with IC50 value of 77 ± 40 μM.

KW - Cisplatin

KW - Cytotoxicity

KW - Metallodrugs

KW - Phenolato ligands

KW - Titanium(IV)

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DO - 10.1016/j.inoche.2015.01.019

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AN - SCOPUS:84920998718

SN - 1387-7003

VL - 53

SP - 31

EP - 33

JO - Inorganic Chemistry Communications

JF - Inorganic Chemistry Communications

ER -

Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands

Abstract

Bibliographical note

Keywords

UN SDGs

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