Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands

Hagai Glasner, Edit Y. Tshuva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Binuclear O-bridged titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands were obtained from the corresponding ligands and Ti(OiPr)4 and analyzed by 1H, 13C and diffusion NMR. The comparative hydrolytic stability in 1:9 D2O/DMSO-d6 was assessed by 1H NMR, and the complexes featured t1/2 values of above 100 h. The cytotoxic activity of the binuclear complexes was measured toward human colon HT-29 cancer cell line by the MTT assay. Although as expected most complexes exhibited mild or no cytotoxic activity, one leading complex demonstrated marked activity with IC50 value of 77 ± 40 μM.

Original languageAmerican English
Pages (from-to)31-33
Number of pages3
JournalInorganic Chemistry Communications
Volume53
DOIs
StatePublished - May 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

  • Cisplatin
  • Cytotoxicity
  • Metallodrugs
  • Phenolato ligands
  • Titanium(IV)

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