TY - JOUR
T1 - d-Poly(lactide) and LHRH decapeptide stereointeractions investigated by vibrational spectroscopy
AU - Zhang, Jianming
AU - Beshra, Ashgan
AU - Domb, Abraham J.
AU - Ozaki, Yukihiro
PY - 2007/7
Y1 - 2007/7
N2 - The interactions between poly(d-lactic acid) (PDLA) and l-configured leuprolide (LHRH) to form heterocomplexes were investigated by a combination of infrared (IR), Raman and near infrared spectroscopy (NIR). It was found that an α crystal with 103 helical conformation of PDLA is formed in the PDLA/LHRH heterocomplexes with various LHRH loadings, whereas the secondary structures of LHRH in these heterocompelexes are greatly affected by the blend ratio of LHRH and PDLA. Based on the analysis of IR, Raman and NIR spectra of the various heterocomplexes, it is suggested that stereoselective Van der Waals interactions, consisting of interwined α helices of PDLA and LHRH, is responsible for the driving force of PDLA and LHRH stereocomplexation. To clarify the solid structure and the potential interaction in these heterocomplexes with various LHRH loadings, temperature-dependent IR spectral measurements were also employed. On the basis of the results presented, a model for the PDLA and LHRH stereointeraction process was proposed.
AB - The interactions between poly(d-lactic acid) (PDLA) and l-configured leuprolide (LHRH) to form heterocomplexes were investigated by a combination of infrared (IR), Raman and near infrared spectroscopy (NIR). It was found that an α crystal with 103 helical conformation of PDLA is formed in the PDLA/LHRH heterocomplexes with various LHRH loadings, whereas the secondary structures of LHRH in these heterocompelexes are greatly affected by the blend ratio of LHRH and PDLA. Based on the analysis of IR, Raman and NIR spectra of the various heterocomplexes, it is suggested that stereoselective Van der Waals interactions, consisting of interwined α helices of PDLA and LHRH, is responsible for the driving force of PDLA and LHRH stereocomplexation. To clarify the solid structure and the potential interaction in these heterocomplexes with various LHRH loadings, temperature-dependent IR spectral measurements were also employed. On the basis of the results presented, a model for the PDLA and LHRH stereointeraction process was proposed.
KW - d-Lactic acid
KW - Heterocomplexes
KW - IR spectral measurements
KW - l-Configured leuprolide
UR - http://www.scopus.com/inward/record.url?scp=34347327085&partnerID=8YFLogxK
U2 - 10.1016/j.eurpolymj.2007.04.035
DO - 10.1016/j.eurpolymj.2007.04.035
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AN - SCOPUS:34347327085
SN - 0014-3057
VL - 43
SP - 3016
EP - 3027
JO - European Polymer Journal
JF - European Polymer Journal
IS - 7
ER -