d-Poly(lactide) and LHRH decapeptide stereointeractions investigated by vibrational spectroscopy

Jianming Zhang, Ashgan Beshra, Abraham J. Domb*, Yukihiro Ozaki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The interactions between poly(d-lactic acid) (PDLA) and l-configured leuprolide (LHRH) to form heterocomplexes were investigated by a combination of infrared (IR), Raman and near infrared spectroscopy (NIR). It was found that an α crystal with 103 helical conformation of PDLA is formed in the PDLA/LHRH heterocomplexes with various LHRH loadings, whereas the secondary structures of LHRH in these heterocompelexes are greatly affected by the blend ratio of LHRH and PDLA. Based on the analysis of IR, Raman and NIR spectra of the various heterocomplexes, it is suggested that stereoselective Van der Waals interactions, consisting of interwined α helices of PDLA and LHRH, is responsible for the driving force of PDLA and LHRH stereocomplexation. To clarify the solid structure and the potential interaction in these heterocomplexes with various LHRH loadings, temperature-dependent IR spectral measurements were also employed. On the basis of the results presented, a model for the PDLA and LHRH stereointeraction process was proposed.

Original languageEnglish
Pages (from-to)3016-3027
Number of pages12
JournalEuropean Polymer Journal
Volume43
Issue number7
DOIs
StatePublished - Jul 2007

Keywords

  • d-Lactic acid
  • Heterocomplexes
  • IR spectral measurements
  • l-Configured leuprolide

Fingerprint

Dive into the research topics of 'd-Poly(lactide) and LHRH decapeptide stereointeractions investigated by vibrational spectroscopy'. Together they form a unique fingerprint.

Cite this