Decrypting UFMylation: How proteins are modified with UFM1

Sayanika Banerjee; Manoj Kumar; Reuven Wiener

doi:10.3390/biom10101442

Decrypting UFMylation: How proteins are modified with UFM1

Sayanika Banerjee, Manoj Kumar, Reuven Wiener^*

^*Corresponding author for this work

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

Besides ubiquitin (Ub), humans have a set of ubiquitin-like proteins (UBLs) that can also covalently modify target proteins. To date, less is known about UBLs than Ub and even less is known about the UBL called ubiquitin-fold modifier 1 (UFM1). Currently, our understanding of protein modification by UFM1 (UFMylation) is like a jigsaw puzzle with many missing pieces, and in some cases it is not even clear whether these pieces of data are in the right place. Here we review the current data on UFM1 from structural biology to biochemistry and cell biology. We believe that the physiological significance of protein modification by UFM1 is currently underestimated and there is more to it than meets the eye.

Original language	English
Article number	1442
Pages (from-to)	1-14
Number of pages	14
Journal	Biomolecules
Volume	10
Issue number	10
DOIs	https://doi.org/10.3390/biom10101442
State	Published - Oct 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Conjugating enzymes
UBA5
UFC1
UFL1
UFM1
UFMylation
Ubiquitin-like proteins

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10.3390/biom10101442

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abstract = "Besides ubiquitin (Ub), humans have a set of ubiquitin-like proteins (UBLs) that can also covalently modify target proteins. To date, less is known about UBLs than Ub and even less is known about the UBL called ubiquitin-fold modifier 1 (UFM1). Currently, our understanding of protein modification by UFM1 (UFMylation) is like a jigsaw puzzle with many missing pieces, and in some cases it is not even clear whether these pieces of data are in the right place. Here we review the current data on UFM1 from structural biology to biochemistry and cell biology. We believe that the physiological significance of protein modification by UFM1 is currently underestimated and there is more to it than meets the eye.",

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Decrypting UFMylation: How proteins are modified with UFM1

Abstract

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Keywords

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