Deep brain stimulation: current challenges and future directions

Andres M. Lozano*, Nir Lipsman, Hagai Bergman, Peter Brown, Stephan Chabardes, Jin Woo Chang, Keith Matthews, Cameron C. McIntyre, Thomas E. Schlaepfer, Michael Schulder, Yasin Temel, Jens Volkmann, Joachim K. Krauss

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

661 Scopus citations


The clinical use of deep brain stimulation (DBS) is among the most important advances in the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly measure pathological brain activity and can deliver adjustable stimulation for therapeutic effect in neurological and psychiatric disorders correlated with dysfunctional circuitry. The development of DBS has opened new opportunities to access and interrogate malfunctioning brain circuits and to test the therapeutic potential of regulating the output of these circuits in a broad range of disorders. Despite the success and rapid adoption of DBS, crucial questions remain, including which brain areas should be targeted and in which patients. This Review considers how DBS has facilitated advances in our understanding of how circuit malfunction can lead to brain disorders and outlines the key unmet challenges and future directions in the DBS field. Determining the next steps in DBS science will help to define the future role of this technology in the development of novel therapeutics for the most challenging disorders affecting the human brain.

Original languageAmerican English
Pages (from-to)148-160
Number of pages13
JournalNature Reviews Neurology
Issue number3
StatePublished - 1 Mar 2019

Bibliographical note

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© 2019, Springer Nature Limited.


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